dentate gyrus of hippocampal formation granule cell
lateral hypothalamus
dorsomedial hypothalamic nucleus
pontine nuclei
cerebellar cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
hydrolase activity
lysophospholipase activity
acylglycerol lipase activity
palmitoyl-(protein) hydrolase activity
Cellular component
integral component of membrane
plasma membrane
AMPA glutamate receptor complex
membrane
cytoplasm
dendrite cytoplasm
Biological process
acylglycerol catabolic process
phosphatidylserine catabolic process
adult walking behavior
response to auditory stimulus
monoacylglycerol catabolic process
glycerophospholipid catabolic process
protein depalmitoylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
26090
76192
Ensembl
ENSG00000100997
ENSMUSG00000032046
UniProt
Q8N2K0
Q99LR1
RefSeq (mRNA)
NM_001042472 NM_015600
NM_024465 NM_001356549 NM_001356550
RefSeq (protein)
NP_001035937 NP_056415
NP_077785 NP_001343478 NP_001343479
Location (UCSC)
Chr 20: 25.29 – 25.39 Mb
Chr 2: 150.67 – 150.75 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system.[5] It is responsible for about 9% of brain 2-AG hydrolysis.[5] Together, ABHD12 along with two other enzymes, monoacylglycerol lipase (MAGL) and ABHD6, control 99% of 2-AG hydrolysis in the brain.[5] ABHD12 also serves as a lysophospholipase and metabolizes lysophosphatidylserine (LPS).[6]
^ abcGRCh38: Ensembl release 89: ENSG00000100997 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032046 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcSavinainen JR, Saario SM, Laitinen JT (February 2012). "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiologica. 204 (2): 267–76. doi:10.1111/j.1748-1716.2011.02280.x. PMC 3320662. PMID 21418147.
^Parkkari T, Haavikko R, Laitinen T, Navia-Paldanius D, Rytilahti R, Vaara M, et al. (2014). "Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12)". PLOS ONE. 9 (5): e98286. Bibcode:2014PLoSO...998286P. doi:10.1371/journal.pone.0098286. PMC 4045134. PMID 24879289.
alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid...
brain 2-AG hydrolysis activity has been estimated to be ~85% (ABHD6 and ABHD12 are responsible for ~4% and ~9%, respectively, of the remainder), and this...
4% of 2-AG brain hydrolysis. Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain, and each enzyme...
Global Information
