Triglyceride lipases (EC 3.1.1.3) are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides.[1] Lipases are widely distributed in animals, plants and prokaryotes.
At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL).[2]
The most conserved region in all these proteins is centred on a serine residue which has been shown[3] to participate, with a histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase (EC 2.3.1.43) (LCAT),[4] which catalyzes fatty acid transfer between phosphatidylcholine and cholesterol.
^Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase". Biochimie. 70 (9): 1223–1234. doi:10.1016/0300-9084(88)90188-5. PMID 3147715.
^Persson B, Bengtsson-Olivecrona G, Enerback S, Olivecrona T, Jornvall H (1989). "Structural features of lipoprotein lipase. Lipase family relationships, binding interactions, non-equivalence of lipase cofactors, vitellogenin similarities and functional subdivision of lipoprotein lipase". Eur. J. Biochem. 179 (1): 39–45. doi:10.1111/j.1432-1033.1989.tb14518.x. PMID 2917565.
^Blow D (1990). "Enzymology. More of the catalytic triad". Nature. 343 (6260): 694–695. Bibcode:1990Natur.343..694B. doi:10.1038/343694a0. PMID 2304545. S2CID 4281247.
^McLean J, Fielding C, Drayna D, Dieplinger H, Baer B, Kohr W, Henzel W, Lawn R (1986). "Cloning and expression of human lecithin-cholesterol acyltransferase cDNA". Proc. Natl. Acad. Sci. U.S.A. 83 (8): 2335–2339. Bibcode:1986PNAS...83.2335M. doi:10.1073/pnas.83.8.2335. PMC 323291. PMID 3458198.
and 27 Related for: Pancreatic lipase family information
higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC 3.1.1.34), which...
to other lipasefamilies. DAGLA; DAGLB; LOC221955; The pancreatic enzyme acts only on an ester-water interface. Other names include lipase, butyrinase...
types of pancreatic cancer are known. The most common, pancreatic adenocarcinoma, accounts for about 90% of cases, and the term "pancreatic cancer" is...
small intestines. Chemicals from the pancreas (pancreaticlipasefamily and bile salt-dependent lipase) are secreted into the small intestines to help...
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine...
member of the lipase gene family, which includes pancreaticlipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes...
pancreatitis is based on a threefold increase in the blood of either amylase or lipase. In chronic pancreatitis, these tests may be normal. Medical imaging such...
Gastric lipase, together with lingual lipase, comprise the two acidic lipases. These lipases, unlike alkaline lipases (such as pancreaticlipase), do not...
CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreaticlipase. It is secreted by the pancreas in an inactive form, procolipase,...
the pancreas (which may be measured concurrently with the more specific lipase), perforated peptic ulcer, torsion of an ovarian cyst, strangulation, ileus...
CT scans, and through blood tests such as measurement of the amylase and lipase enzymes.: 888–894 Diseases of the hepatobiliary system affect the biliary...
Gram-positive bacterium belonging to the genus Streptomyces. It produces the pancreaticlipase inhibitor lipstatin, of which the antiobesity drug orlistat is a derivative...
lipase plays a large role in fat digestion in newborn infants as their pancreaticlipase still needs some time to develop. Saliva is very important in the...
hydrolase, cholesterol ester hydrolase, cholesterase, and acylcholesterol lipase. This enzyme participates in bile acid biosynthesis. Hyun J, Kothari H,...
atypical member of the ANGPTL family. It shares with ANGPTL4 and ANGPTL8 the ability to inhibit the enzyme Lipoprotein lipase (LPL), and its hepatic overexpression...
found it to have 4,285 genes. M. globosa uses eight different types of lipase, along with three phospholipases, to break down the oils on the scalp. Any...
in pancreatic islet α cells. In intestinal L cells, proglucagon is cleaved to the alternate products glicentin (1–69), glicentin-related pancreatic polypeptide...
no free glycerol) by pancreaticlipase, which forms a 1:1 complex with a protein called colipase (also a constituent of pancreatic juice), which is necessary...
are consumed in salads or herbal tea with the effect of inhibiting pancreaticlipase. According to a Pakistani team (2017), in rats subjected to a high...
the small intestine produces hormones that stimulate the release of pancreaticlipase from the pancreas and bile from the liver which helps in the emulsification...
Increased gastrin secretion increases gastric acid, which may inactivate pancreaticlipase, leading to diarrhea and steatorrhea. Increased gastrin secretion...
from the pancreas (e.g., pancreatic amylase and pancreaticlipase) to function optimally. Secretin targets the pancreas; pancreatic centroacinar cells have...
useful for electrolyte and metabolic abnormalities. Liver function tests and lipase would identify pancreaticobiliary diseases. Abdominal X-rays showing air-fluid...
count, basic metabolic panel, electrolytes, liver function tests, amylase, lipase, troponin I, and for females, a serum pregnancy test. Urinalysis Imaging...
Extracts from Picea abies have shown inhibitory activity on porcine pancreaticlipase in vitro. Picea abies (L.) H. Karst is the accepted name of this species...
should be ordered include a complete blood count, liver function tests and lipase. In biliary colic, lab findings are usually within normal limits. Alanine...
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