Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression.[5] It may alternatively be classified as a tricyclic antidepressant (TCA), specifically a secondary amine.[5] In terms of its chemistry and pharmacology, maprotiline is closely related to such-other secondary-amine TCAs as nortriptyline and protriptyline and has similar effects to them,[6][5] albeit with more distinct anxiolytic effects.[7][8][9] Additionally, whereas protriptyline tends to be somewhat more stimulating and in any case is distinctly more-or-less non-sedating,[10] mild degrees of sedation may be experienced with maprotiline.[11]
^Cite error: The named reference Elks2014 was invoked but never defined (see the help page).
^Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).
^Cite error: The named reference Drugs.com was invoked but never defined (see the help page).
^Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ abcCite error: The named reference LemkeWilliams2012 was invoked but never defined (see the help page).
^Cite error: The named reference Zhou2013 was invoked but never defined (see the help page).
^Guimarães FS, Zuardi AW, Graeff FG (January 1987). "Effect of chlorimipramine and maprotiline on experimental anxiety in humans". Journal of Psychopharmacology. 1 (3): 184–192. doi:10.1177/026988118700100305. PMID 22158980. S2CID 8444656.
^Vinader-Caerols C, Martos AJ, Monleón S, Arenas MC, Parra A (2006). "Acute effects of maprotiline on learning, anxiety, activity and analgesia in male and female mice". Acta Neurobiologiae Experimentalis. 66 (1): 23–31. doi:10.55782/ane-2006-1584. PMID 16617674.
^Pecknold JC, Familamiri P, McClure DJ, Elie R, Chang H (May 1985). "Trimipramine and maprotiline: antidepressant, anxiolytic, and cardiotoxic comparison". The Journal of Clinical Psychiatry. 46 (5): 166–171. PMID 2859273.
^Brownell LG, Perez-Padilla R, West P, Kryger MH (1983). "The role of protriptyline in obstructive sleep apnea". Bulletin Européen de Physiopathologie Respiratoire. 19 (6): 621–4. PMID 6360257.
^Holmberg G (May 1988). "Sedative effects of maprotiline and amitriptyline". Acta Psychiatrica Scandinavica. 77 (5): 584–6. doi:10.1111/j.1600-0447.1988.tb05171.x. PMID 3044007. S2CID 41977086.
Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression. It may...
tricyclic antidepressants (TCAs), which contain three rings of atoms. Maprotiline (Ludiomil) – can also be classified as a TCA and grouped with the secondary...
of the tricyclics (e.g., clomipramine, amitriptyline, nortriptyline, maprotiline), which is why it may feature sometimes in the discussion of depression...
actually not a TCA but a tricyclic-like antidepressant Amoxapine (Asendin) Maprotiline (Ludiomil) Mianserin (Tolvon) Mirtazapine (Remeron) Setiptiline (Tecipul)...
Antidepressants with a tetracyclic structure such as mianserin and maprotiline were first developed in the 1970s as tetracyclic antidepressants. Loratadine...
open clinical study in out-patients and of a double-blind study against maprotiline.". Psychiatry the State of the Art. Boston, MA.: Springer. pp. 283–289...