translation release factor activity, codon specific
ribosome binding
Cellular component
mitochondrion
cytoplasm
Biological process
translational termination
regulation of translational termination
protein biosynthesis
mitochondrial translational termination
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9617
211253
Ensembl
ENSG00000120662
ENSMUSG00000022022
UniProt
O75570 Q8N6Z2
Q8K126
RefSeq (mRNA)
NM_004294 NM_001354073 NM_001354074 NM_001354076
NM_145960
RefSeq (protein)
NP_004285 NP_001341002 NP_001341003 NP_001341005
NP_666072
Location (UCSC)
Chr 13: 41.22 – 41.26 Mb
Chr 14: 79.64 – 79.66 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitochondrial translational release factor 1, also known as MTRF1 is a human gene.[5][6]
The protein encoded by this gene directs the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis. mtRF1 has been hypothesized to recognize non-standard stop codons AGA and AGG in vertebrates. Alternatively, based on detailed 3D modelling, it has been proposed to recognize stalled ribosomes in which a tRNA is still bound to the peptide chain, but in which the A-site of the ribosome is empty.
^ abcGRCh38: Ensembl release 89: ENSG00000120662 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022022 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhang Y, Spremulli LL (November 1998). "Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 245–50. doi:10.1016/S0167-4781(98)00223-1. PMID 9838146.
^Hansen LL, Jørgensen R, Justesen J (2000). "Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1→q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32→q34.1 with radiation hybrid mapping". Cytogenetics and Cell Genetics. 88 (1–2): 91–2. doi:10.1159/000015494. PMID 10773675. S2CID 1354562.
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Mitochondrialtranslationalreleasefactor1, also known as MTRF1 is a human gene. The protein encoded by this gene directs the termination of translation...
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Global Information
