This article is about adrenocorticotropic hormone as a natural hormone. For adrenocorticotropic hormone as a medication and diagnostic agent, see Adrenocorticotropic hormone (medication).
pro-opiomelanocortin
Identifiers
Symbol
OMC
NCBI gene
5443
HGNC
9201
OMIM
176830
RefSeq
NM_000939
UniProt
P01189
Other data
Locus
Chr. 2 p23
Search for
Structures
Swiss-model
Domains
InterPro
proopiomelanocortin derivatives
POMC
γ-MSH
ACTH
β-lipotropin
α-MSH
CLIP
γ-lipotropin
β-endorphin
β-MSH
Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.[1] It is also used as a medication and diagnostic agent. ACTH is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of cortisol and androgens by the zona fasiculata and zona reticularis, respectively. ACTH is also related to the circadian rhythm in many organisms.[2]
Deficiency of ACTH is an indicator of secondary adrenal insufficiency (suppressed production of ACTH due to an impairment of the pituitary gland or hypothalamus, cf. hypopituitarism) or tertiary adrenal insufficiency (disease of the hypothalamus, with a decrease in the release of corticotropin releasing hormone (CRH)). Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency (e.g. Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease a pituitary tumor is the cause of elevated ACTH (from the anterior pituitary) and an excess of cortisol (hypercortisolism) – this constellation of signs and symptoms is known as Cushing's syndrome.
^Morton IK, Hall JM (December 6, 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 84–. ISBN 978-94-011-4439-1.
^Dibner C, Schibler U, Albrecht U (2010). "The mammalian circadian timing system: organization and coordination of central and peripheral clocks" (PDF). Annual Review of Physiology. 72: 517–49. doi:10.1146/annurev-physiol-021909-135821. PMID 20148687.
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thyroid-stimulating hormone (TSH). Prostaglandins are now known to inhibit adrenocorticotropichormone (ACTH) and also to stimulate TSH, GH and LH release. Clinical...
located in the cytoplasm or nucleus by an intracrine mechanism. Adrenocorticotropichormone (ACTH) Aadropin Aamylin Aangiotensin Aatrial natriuretic peptide...
The following is a list of hormones found in Homo sapiens. Spelling is not uniform for many hormones. For example, current North American and international...
adrenocorticotropichormone (ACTH) in the pituitary gland) or tertiary adrenal insufficiency (when caused by lack of corticotropin-releasing hormone (CRH)...
thyroid hormone inhibits it. Adrenocorticotropichormone stimulates the adrenal cortex to release corticosteroids. Adrenocorticotropichormone release...
potassium as probably determined by sensors in the carotid artery. Adrenocorticotropichormone (ACTH), a pituitary peptide, also has some stimulating effect...
gland. They include thyroid stimulating hormone (TSH), gonadotropic hormones (FSH, LH), adrenocorticotropichormone, and prolactin.[citation needed] An MRI...
cells. Adrenocorticotropichormone (ACTH or corticotropin) – stimulates the adrenal cortex increasing the size and number of cells. Luteinizing hormone (LH)/...
anterior pituitary. The anterior pituitary in turn releases adrenocorticotropichormone (ACTH). ACTH induces the release of corticosteroids and aldosterone...
stimulates the thyroid gland to make and release thyroid hormone.: 718 Adrenocorticotropichormone (ACTH or corticotropin) – stimulates the adrenal cortex...
under certain circumstances, indirectly inhibits release of adrenocorticotropichormone and cortisol and, in those situations, may be considered an antagonist...
level of cortisol but can also produce bursts of the hormone in response to adrenocorticotropichormone (ACTH) from the anterior pituitary. Cortisol is not...
They contain significantly greater quantities of the hormones prolactin, adrenocorticotropichormone, and Leu-enkephalin, and the elements potassium and...
Cushing's disease is characterized by the hypersecretion of the adrenocorticotropichormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous...
neurohormones, called releasing hormones or hypothalamic hormones, and these in turn stimulate or inhibit the secretion of hormones from the pituitary gland...
memory. Children experience growth retardation and short stature. Adrenocorticotropichormone (ACTH) deficiency leads to adrenal insufficiency, a lack of production...
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