COA3 information

COA3
Identifiers
Aliases	COA3, CCDC56, MITRAC12, HSPC009, cytochrome c oxidase assembly factor 3, COX25, MC4DN14, hCOA3
External IDs	OMIM: 614775; MGI: 1098757; HomoloGene: 69156; GeneCards: COA3; OMA:COA3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,798,704 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,169,940 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; corpus epididymis; ; renal medulla; ; body of pancreas; ; mucosa of sigmoid colon; ; oral cavity; ; duodenum; ; body of stomach; ; gums; ; gingival epithelium;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; medullary collecting duct; ; islet of Langerhans; ; migratory enteric neural crest cell; ; epithelium of stomach; ; transitional epithelium of urinary bladder; ; lobe of prostate; ; medial ganglionic eminence; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; integral component of mitochondrial inner membrane; mitochondrial respiratory chain complex IV;
Biological process	mitochondrial cytochrome c oxidase assembly; positive regulation of mitochondrial translation;
	Sources:Amigo / QuickGO
Orthologs
	28958
	52469
	ENSG00000183978
	ENSMUSG00000017188
	Q9Y2R0
	Q9D2R6
	NM_001040431; NM_014019
	NM_026618
	NP_001035521
	NP_080894
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase assembly factor 3, also known as Coiled-coil domain-containing protein 56, or Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa is a protein that in humans is encoded by the COA3 gene. This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183978 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017188 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "COA3 - Cytochrome c oxidase assembly factor 3 homolog, mitochondrial - Homo sapiens (Human) - COA3 gene & protein". Retrieved 2018-08-07. This article incorporates text available under the CC BY 4.0 license.
^ "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.
^ "Entrez Gene: Cytochrome c oxidase assembly factor 3". Retrieved 2018-08-07.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183978 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017188 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot0-5] "COA3 - Cytochrome c oxidase assembly factor 3 homolog, mitochondrial - Homo sapiens (Human) - COA3 gene & protein". Retrieved 2018-08-07. This article incorporates text available under the CC BY 4.0 license.

[uniprot2-6] "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.

[entrez-7] "Entrez Gene: Cytochrome c oxidase assembly factor 3". Retrieved 2018-08-07.

COA3 information

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