Tissue damage after return of blood supply following ischemia or hypoxia
Medical condition
Reperfusion injury
Other names
Reperfusion insult
Native records of contractile activity of the left ventricle of isolated rat heart perfused under Langendorff technique. Curve A - contractile function of the heart is greatly depressed after ischemia-reperfusion. Curve B - a set of short ischemic episodes (ischemic preconditioning) before prolonged ischemia provides functional recovery of contractile activity of the heart at reperfusion.
Specialty
Cardiology
Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia). The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than (or along with) restoration of normal function.
Reperfusion injury is distinct from cerebral hyperperfusion syndrome (sometimes called "Reperfusion syndrome"), a state of abnormal cerebral vasodilation.
and 26 Related for: Reperfusion injury information
Reperfusioninjury, sometimes called ischemia-reperfusioninjury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to...
Reperfusion is the restoration of blood flow to an organ or tissue after having been blocked, and may refer to: Reperfusioninjury, tissue damage caused...
reduce the risk of recurrence or progression. With reperfusion comes ischemia/reperfusion (IR) injury (IRI), which paradoxically causes cell death in reperfused...
been implicated in the reperfusioninjury through increased ROS production. During ischemia, succinate accumulates. Upon reperfusion, succinate is rapidly...
reperfusioninjury. For frostbite injuries, limiting thawing and warming of tissues until warmer temperatures can be sustained may reduce reperfusion...
lead to generation of oxygen free radicals, which have a role in reperfusioninjury after asphyxia. Research by Ola Didrik Saugstad and others led to...
bypass grafting can produce renal ischemia and reperfusioninjury. This could lead to an acute kidney injury. Moreover, renal ischemia can cause the delay...
congested from sluggish venous outflow reperfusion (injury) of previously ischemic tissue that is associated with reperfusion-related diseases, such as myocardial...
increase in ROS production during early (3 min) reperfusion, and activation of the reperfusioninjury salvage kinase pathway (RISK). The mitochondrial...
obstruction, effectively a form of negative pressure pulmonary oedema. Reperfusioninjury, i.e., postpulmonary thromboendartectomy or lung transplantation Swimming...
01 °F) may cause frostbite. Rewarming causes tissue damage through reperfusioninjury, which involves vasodilation, swelling (edema), and poor blood flow...
Reperfusion therapy is a medical treatment to restore blood flow, either through or around, blocked arteries, typically after a heart attack (myocardial...
While reperfusion may be essential to protecting as much brain tissue as possible, it may also lead to reperfusioninjury. Reperfusioninjury is classified...
from reperfusioninjury and hypoperfusion related to shock. Compartment syndrome. Compartment syndrome is a common complication of crush injury as a consequence...
School in 1995 with a thesis entitled In vivo studies of ischaemia-reperfusioninjury in hypothermically stored rabbit renal autograft. He then worked as...
mitochondrial complex I has been shown to occur during ischemia/reperfusion brain injury during stroke. Flavin mononucleotide is also used as an orange-red...
studies. The drug is a potential first-in-class agent for prevention of reperfusioninjury in CABG surgery. Schering began patient enrollment in phase III studies...
tissue damage, including myocardial infarction, stroke, ischemia-reperfusioninjury. In addition, necroptosis is noted to contribute to atherosclerosis...
ability to ameliorate neuronal cellular damage and reperfusioninjury (phase III) in traumatic brain injury. This multi-center study is being organized by...
concentrations increase in response to atherosclerosis, ischemia/reperfusion-injury and heart failure. In patients with coronary artery disease (CAD)...
oxygen species (ROS) release during oxidative stress by ischemia-reperfusioninjury, specifically in the myocardium as part of a heart attack (also known...
Abnormalities in microcirculation within the testicle Reperfusioninjury: This type of injury is seen in tissues that have been deprived of blood supply...
blood flow may be present. The Pringle manoeuvre can directly lead to reperfusioninjury in the liver, causing impaired function. This is particularly true...
complications such as limb amputation, metabolic acidosis, and severe reperfusioninjury have all been reported with REBOA use and are the subjects of ongoing...
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