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Mitochondrial permeability transition pore information


The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke. Opening allows increase in the permeability of the mitochondrial membranes to molecules of less than 1500 daltons in molecular weight. Induction of the permeability transition pore, mitochondrial membrane permeability transition (mPT or MPT), can lead to mitochondrial swelling and cell death through apoptosis or necrosis depending on the particular biological setting.[1]

  1. ^ Lemasters, J. J.; Theruvath, T. P.; Zhong, Z.; Nieminen, A. L. (2009). "Mitochondrial calcium and the permeability transition in cell death". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787 (11): 1395–1401. doi:10.1016/j.bbabio.2009.06.009. PMC 2730424. PMID 19576166.

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Mitochondrial permeability transition pore

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The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of...

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an ischemic event is termed “reperfusion injury”. The mitochondrial permeability transition pore (mPTP) is normally closed during ischemia, but calcium...

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Y (December 1998). "Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria"...

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genetic control of necrosis-like cell death through the mitochondrial permeability transition pore". Molecular and Cellular Biology. 20 (15): 5454–68. doi:10...

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the mitochondrial electron transport chain leads to additional mitochondrial damage and opening of the mitochondrial permeability transition pore, which...

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structural component of the mitochondrial permeability transition pore. The pore opening raises the permeability of the mitochondrial inner membrane, allows...

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c-subunit has been indicated as a critical component of the mitochondrial permeability transition pore. ATPase, Vo complex, proteolipid subunit C, InterPro: IPR000245...

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suggests that activated BAX and/or Bak form an oligomeric pore, MAC in the MOM (mitochondrial outer membrane). This results in the release of cytochrome...

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important modulatory and possible structural component of the Mitochondrial Permeability Transition Pore, a channel involved in various pathologies whose function...

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homolog Entosis Excitotoxicity Ferroptosis Inflammasome Mitochondrial permeability transition pore Mitotic catastrophe Necrobiology Necroptosis Necrosis...

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translocator, but it does lead to delayed opening of the mitochondrial permeability transition pore, thus allowing for greater sequestration of calcium. Furthermore...

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HK1 binds VDAC1 to trigger opening of the mitochondrial permeability transition pore and release mitochondrial ATP to further fuel the glycolytic process...

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PB1 RNA segment and "interacts with 2 components of the mitochondrial permeability transition pore complex, ANT3 and VDCA1, [sensitizing] cells to apoptosis...

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intermediates, and regulate cell death through activation of the mitochondrial permeability transition pore (mtPTP). When they fail, less and less energy is generated...

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response can be exploited for detecting the opening of the mitochondrial permeability transition pore (mPTP) and for measuring cell volume changes. Calcein...

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