Mitochondrial permeability transition pore information
Protein
The mitochondrial permeability transition pore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of the mitochondria under certain pathological conditions such as traumatic brain injury and stroke. Opening allows increase in the permeability of the mitochondrial membranes to molecules of less than 1500 daltons in molecular weight. Induction of the permeability transition pore, mitochondrial membrane permeability transition (mPT or MPT), can lead to mitochondrial swelling and cell death through apoptosis or necrosis depending on the particular biological setting.[1]
^Lemasters, J. J.; Theruvath, T. P.; Zhong, Z.; Nieminen, A. L. (2009). "Mitochondrial calcium and the permeability transition in cell death". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787 (11): 1395–1401. doi:10.1016/j.bbabio.2009.06.009. PMC 2730424. PMID 19576166.
and 26 Related for: Mitochondrial permeability transition pore information
The mitochondrialpermeabilitytransitionpore (mPTP or MPTP; also referred to as PTP, mTP or MTP) is a protein that is formed in the inner membrane of...
so-called mitochondrialpermeabilitytransitionpore (MPT pore) in the mitochondrial membrane of cardiac cells. The opening of the MPT pore leads to the...
the tissues. Examples of mitochondrial transport proteins include the following: The mitochondrialpermeabilitytransitionpore, which opens in response...
mitochondrialpermeabilitytransitionpore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases...
an ischemic event is termed “reperfusion injury”. The mitochondrialpermeabilitytransitionpore (mPTP) is normally closed during ischemia, but calcium...
Y (December 1998). "Bax interacts with the permeabilitytransitionpore to induce permeabilitytransition and cytochrome c release in isolated mitochondria"...
genetic control of necrosis-like cell death through the mitochondrialpermeabilitytransitionpore". Molecular and Cellular Biology. 20 (15): 5454–68. doi:10...
the mitochondrial electron transport chain leads to additional mitochondrial damage and opening of the mitochondrialpermeabilitytransitionpore, which...
shown that the compound inhibits Mitochondrialpermeabilitytransitionpore (MPTP) by inhibiting the activity of the pore regulator, cyclophilin D (CyP-D)...
structural component of the mitochondrialpermeabilitytransitionpore. The pore opening raises the permeability of the mitochondrial inner membrane, allows...
c-subunit has been indicated as a critical component of the mitochondrialpermeabilitytransitionpore. ATPase, Vo complex, proteolipid subunit C, InterPro: IPR000245...
suggests that activated BAX and/or Bak form an oligomeric pore, MAC in the MOM (mitochondrial outer membrane). This results in the release of cytochrome...
protein, a liver protein linked to LDL release MitochondrialpermeabilitytransitionporeMitochondrial trifunctional protein, a protein which catalyzes...
important modulatory and possible structural component of the MitochondrialPermeabilityTransitionPore, a channel involved in various pathologies whose function...
excess calcium in the cytosol is the opening of the mitochondrialpermeabilitytransitionpore, a pore in the membranes of mitochondria that opens when the...
translocator, but it does lead to delayed opening of the mitochondrialpermeabilitytransitionpore, thus allowing for greater sequestration of calcium. Furthermore...
2004). "The ADP/ATP translocator is not essential for the mitochondrialpermeabilitytransitionpore". Nature. 427 (6973): 461–5. Bibcode:2004Natur.427..461K...
HK1 binds VDAC1 to trigger opening of the mitochondrialpermeabilitytransitionpore and release mitochondrial ATP to further fuel the glycolytic process...
PB1 RNA segment and "interacts with 2 components of the mitochondrialpermeabilitytransitionpore complex, ANT3 and VDCA1, [sensitizing] cells to apoptosis...
did so through interactions with two components of the mitochondrialpermeabilitytransitionpore (mPTP), VDAC and TSPO. In preclinical studies on Huntington's...
intermediates, and regulate cell death through activation of the mitochondrialpermeabilitytransitionpore (mtPTP). When they fail, less and less energy is generated...
response can be exploited for detecting the opening of the mitochondrialpermeabilitytransitionpore (mPTP) and for measuring cell volume changes. Calcein...