Antamanide information

Antamanide
Identifiers
CAS Number	16898-32-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	2300791 ;
ECHA InfoCard	100.037.203
PubChem CID	9876840;
CompTox Dashboard (EPA)	DTXSID80903964 ;
	InChI InChI=1S/C64H78N10O10/c1-40(2)54-64(84)74-35-19-31-53(74)63(83)71-32-16-28-50(71)59(79)65-41(3)55(75)66-46(36-42-20-8-4-9-21-42)57(77)69-49(39-45-26-14-7-15-27-45)61(81)73-34-18-30-52(73)62(82)72-33-17-29-51(72)60(80)68-47(37-43-22-10-5-11-23-43)56(76)67-48(58(78)70-54)38-44-24-12-6-13-25-44/h4-15,20-27,40-41,46-54H,16-19,28-39H2,1-3H3,(H,65,79)(H,66,75)(H,67,76)(H,68,80)(H,69,77)(H,70,78)/t41-,46-,47-,48-,49-,50-,51-,52-,53-,54-/m0/s1 Key: WTINJQXJTHUFRF-IHTIUHOMSA-N ;
	SMILES C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N1)C(C)C)Cc6ccccc6)Cc7ccccc7)Cc8ccccc8)Cc9ccccc9;
Properties
Chemical formula	C64H78N10O10
Molar mass	1147.36 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Antamanide is a cyclic decapeptide isolated from a fungus, the death cap: Amanita phalloides.^[1] It is being studied as a potential anti-toxin against the effects of phalloidin and for its potential for treating edema.^[2] It contains 1 valine residue, 4 proline residues, 1 alanine residue, and 4 phenylalanine residues with a structure of c(Val-Pro-Pro-Ala-Phe-Phe-Pro-Pro-Phe-Phe). It was isolated by determining the source of the anti-phalloidin activity from a lipophillic extraction from the organism. It has been shown that antamanide can react to form alkali metal ion complexes. These include complexes with sodium and calcium ions. When these complexes are formed, the cyclopeptide structure undergoes a conformational change.^[1]

^ ^a ^b Wieland T, Faulstich H (1978). "Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms". CRC Crit. Rev. Biochem. 5 (3): 185–260. doi:10.3109/10409237809149870. PMID 363352.
^ David Shepro and J. Steven Alexander, Prophylactic and therapeutic methods for treating edema with antamanides. United States Patent 5466667.

[One-1] Wieland T, Faulstich H (1978). "Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms". CRC Crit. Rev. Biochem. 5 (3): 185–260. doi:10.3109/10409237809149870. PMID 363352.

[2] David Shepro and J. Steven Alexander, Prophylactic and therapeutic methods for treating edema with antamanides. United States Patent 5466667.

Antamanide information

and 4 Related for: Antamanide information

Antamanide

Amanita phalloides

Phallolysin

Amanullinic acid

Identifiers

CAS Number	16898-32-1^Y
3D model (JSmol)	Interactive image
ChemSpider	2300791^Y
ECHA InfoCard	100.037.203
PubChem CID	9876840
CompTox Dashboard (EPA)	DTXSID80903964
InChI InChI=1S/C64H78N10O10/c1-40(2)54-64(84)74-35-19-31-53(74)63(83)71-32-16-28-50(71)59(79)65-41(3)55(75)66-46(36-42-20-8-4-9-21-42)57(77)69-49(39-45-26-14-7-15-27-45)61(81)73-34-18-30-52(73)62(82)72-33-17-29-51(72)60(80)68-47(37-43-22-10-5-11-23-43)56(76)67-48(58(78)70-54)38-44-24-12-6-13-25-44/h4-15,20-27,40-41,46-54H,16-19,28-39H2,1-3H3,(H,65,79)(H,66,75)(H,67,76)(H,68,80)(H,69,77)(H,70,78)/t41-,46-,47-,48-,49-,50-,51-,52-,53-,54-/m0/s1^N Key: WTINJQXJTHUFRF-IHTIUHOMSA-N^N
SMILES C[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N1)C(C)C)Cc6ccccc6)Cc7ccccc7)Cc8ccccc8)Cc9ccccc9
Properties
Chemical formula	C₆₄H₇₈N₁₀O₁₀
Molar mass	1147.36 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references