Mitochondrial intermediate peptidase (EC 3.4.24.59, mitochondrial intermediate precursor-processing proteinase, MIP) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction
Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion
This enzyme is a homologue of thimet oligopeptidase.
^Isaya G, Kalousek F, Rosenberg LE (April 1992). "Amino-terminal octapeptides function as recognition signals for the mitochondrial intermediate peptidase". The Journal of Biological Chemistry. 267 (11): 7904–10. doi:10.1016/S0021-9258(18)42598-7. PMID 1560019.
^Isaya G, Kalousek F, Rosenberg LE (September 1992). "Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue". Proceedings of the National Academy of Sciences of the United States of America. 89 (17): 8317–21. doi:10.1073/pnas.89.17.8317. PMC 49909. PMID 1518864.
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