mitochondrial electron transport, ubiquinol to cytochrome c
aerobic respiration
protein processing
proteolysis
mitochondrial calcium ion transmembrane transport
protein processing involved in protein targeting to mitochondrion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
9512
73078
Ensembl
ENSG00000105819
ENSMUSG00000029017
UniProt
O75439
Q9CXT8
RefSeq (mRNA)
NM_004279
NM_028431
RefSeq (protein)
NP_004270
NP_082707
Location (UCSC)
Chr 7: 103.3 – 103.33 Mb
Chr 5: 21.94 – 21.96 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitochondrial-processing peptidase subunit beta is an enzyme that in humans is encoded by the PMPCB gene.[5][6] This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000105819 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029017 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
peptidase subunit beta is an enzyme that in humans is encoded by the PMPCB gene. This gene is a member of the peptidase M16 family and encodes a protein...
this complex is composed of two subunits encoded by the genes PMPCA, and PMPCB. The enzyme is also known as (EC 3.4.24.64, processing enhancing peptidase...
neurodegeneration. Frataxin has been shown to biologically interact with the enzyme PMPCB. GRCh38: Ensembl release 89: ENSG00000165060 – Ensembl, May 2017 GRCm38:...
its catalytic function. Containing the catalytic site, the beta subunit PMPCB protein cleaves presequences (transit peptides) from mitochondrial protein...