MIPEP information

MIPEP
Identifiers
Aliases	MIPEP, HMIP, MIP, mitochondrial intermediate peptidase, COXPD31
External IDs	OMIM: 602241; MGI: 1917728; HomoloGene: 4337; GeneCards: MIPEP; OMA:MIPEP - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	23,889,400 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	61,142,927 bp
RNA expression pattern
	Top expressed in
	right auricle; ; apex of heart; ; gonad; ; left ventricle; ; right uterine tube; ; skin of abdomen; ; skin of leg; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon;
	Top expressed in
	seminiferous tubule; ; spermatid; ; interventricular septum; ; myocardium of ventricle; ; otolith organ; ; utricle; ; oocyte; ; primary oocyte; ; spermatocyte; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	peptide metabolic process; proteolysis; protein processing involved in protein targeting to mitochondrion;
	Sources:Amigo / QuickGO
Orthologs
	4285
	70478
	ENSG00000027001
	ENSMUSG00000021993
	Q99797
	A6H611
	NM_005932
	NM_027436
	NP_005923
	NP_081712
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial intermediate peptidase is an enzyme that in humans is encoded by the MIPEP gene.^[5] This protein is a critical component of human mitochondrial protein import machinery involved in the maturing process of nuclear coded mitochondrial proteins that with a mitochondrial translocation peptide, especially those OXPHOS-related proteins.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000027001 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021993 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MIPEP mitochondrial intermediate peptidase".
^ Chew A, Buck EA, Peretz S, et al. (Mar 1997). "Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP)". Genomics. 40 (3): 493–6. doi:10.1006/geno.1996.4586. PMID 9073519.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000027001 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021993 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MIPEP mitochondrial intermediate peptidase".

[6] Chew A, Buck EA, Peretz S, et al. (Mar 1997). "Cloning, expression, and chromosomal assignment of the human mitochondrial intermediate peptidase gene (MIPEP)". Genomics. 40 (3): 493–6. doi:10.1006/geno.1996.4586. PMID 9073519.