PMPCA information

PMPCA
Identifiers
Aliases	PMPCA, Alpha-MPP, INPP5E, P-55, SCAR2, peptidase, mitochondrial processing alpha subunit, CLA1, CPD3, peptidase, mitochondrial processing subunit alpha, MAS2
External IDs	OMIM: 613036; MGI: 1918568; HomoloGene: 6078; GeneCards: PMPCA; OMA:PMPCA - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,423,761 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,287,134 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; apex of heart; ; right adrenal gland; ; left ventricle; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; gastrocnemius muscle; ; right auricle; ; stromal cell of endometrium;
	Top expressed in
	yolk sac; ; muscle of thigh; ; triceps brachii muscle; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; right ventricle; ; proximal tubule; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity; metallopeptidase activity; metalloendopeptidase activity; zinc ion binding; metal ion binding; catalytic activity; endopeptidase activity;
Cellular component	mitochondrial matrix; mitochondrion; membrane; mitochondrial inner membrane; extracellular space; mitochondrial processing peptidase complex;
Biological process	proteolysis; protein processing involved in protein targeting to mitochondrion; mitochondrial calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	23203
	66865
	ENSG00000165688
	ENSMUSG00000026926
	Q10713; Q5SXN9
	Q9DC61
	NM_001282944; NM_001282946; NM_015160
	NM_173180
	NP_001269873; NP_001269875; NP_055975
	NP_775272
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial-processing peptidase subunit alpha is an enzyme that in humans is encoded by the PMPCA gene.^[5]^[6]^[7] This gene PMPCA encoded a protein that is a member of the peptidase M16 family. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165688 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026926 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
^ "Entrez Gene: PMPCA peptidase (mitochondrial processing) alpha".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165688 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026926 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8590280-5] Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.

[pmid7788527-6] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[entrez-7] "Entrez Gene: PMPCA peptidase (mitochondrial processing) alpha".

PMPCA information

and 4 Related for: PMPCA information

PMPCA

Mitochondrial processing peptidase

Chromosome 9

PMPCB