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Miricorilant (CORT 118335) is a small molecule that works as a selective glucocorticoid receptor modulator and mineralcorticoid receptor antagonist.[1][2][3] It was developed by Corcept Therapeutics for nonalcoholic steatohepatitis[4] and weight gain associated with atypical antipsychotics.[5]
^Mammi, C.; Marzolla, V.; Armani, A.; Feraco, A.; Antelmi, A.; Maslak, E.; Chlopicki, S.; Cinti, F.; Hunt, H.; Fabbri, A.; Caprio, M. (June 2016). "A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet". International Journal of Obesity. 40 (6): 964–972. doi:10.1038/ijo.2016.13. ISSN 1476-5497. PMID 26830012. S2CID 19751493.
^Nguyen, Elizabeth T.; Berman, Sarah; Streicher, Joshua; Estrada, Christina M.; Caldwell, Jody L.; Ghisays, Valentina; Ulrich-Lai, Yvonne; Solomon, Matia B. (1 August 2019). "Effects of combined glucocorticoid/mineralocorticoid receptor modulation (CORT118335) on energy balance, adiposity, and lipid metabolism in male rats". American Journal of Physiology. Endocrinology and Metabolism. 317 (2): E337–E349. doi:10.1152/ajpendo.00018.2019. PMID 31112405. S2CID 162170330.
^Nguyen, Elizabeth T.; Caldwell, Jody L.; Streicher, Joshua; Ghisays, Valentina; Balmer, Nikolaus J.; Estrada, Christina M.; Solomon, Matia B. (January 2018). "Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats". Behavioural Brain Research. 336: 99–110. doi:10.1016/j.bbr.2017.08.045. PMID 28866130. S2CID 5511661.
^Koorneef, Lisa L; van den Heuvel, José K; Kroon, Jan; Boon, Mariëtte R; ’t Hoen, Peter A C; Hettne, Kristina M; van de Velde, Nienke M; Kolenbrander, Kelsey B; Streefland, Trea C M; Mol, Isabel M; Sips, Hetty C M; Kielbasa, Szymon M; Mei, Hailiang; Belanoff, Joseph K; Pereira, Alberto M; Oosterveer, Maaike H; Hunt, Hazel; Rensen, Patrick C N; Meijer, Onno C (12 October 2018). "Selective glucocorticoid receptor modulation prevents and reverses non-alcoholic fatty liver disease in male mice". Endocrinology. 159 (12): 3925–3936. doi:10.1210/en.2018-00671. hdl:1887/79939. PMID 30321321. S2CID 53501584.
^Hunt, Hazel J.; Donaldson, Kirsteen; Strem, Mark; Tudor, Iulia Cristina; Sweet-Smith, Suzanne; Sidhu, Sharan (November–December 2021). "Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study". Journal of Clinical Psychopharmacology. 41 (6): 632–637. doi:10.1097/JCP.0000000000001470. ISSN 1533-712X. PMC 8575171. PMID 34369902.
Miricorilant (CORT 118335) is a small molecule that works as a selective glucocorticoid receptor modulator and mineralcorticoid receptor antagonist. It...
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