A mineralocorticoid receptor antagonist (MRA or MCRA)[1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure. Spironolactone, the first member of the class, is also used in the management of hyperaldosteronism (including Conn's syndrome) and female hirsutism (due to additional antiandrogen actions). Most antimineralocorticoids, including spironolactone, are steroidal spirolactones. Finerenone is a nonsteroidal antimineralocorticoid.
^The Krause/King-Lewis acronym, developed at Naval Medical Center San Diego Archived 2018-07-13 at the Wayback Machine, of MCRA was developed during February 2017 to distinguish between MRA for a specific MRI which are both widely recognized medical acronyms as compared to the use of MRA for mineralocorticoid receptor antagonist type medications which is only used as a medical acronym in the cardiology and nephrology word.
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A mineralocorticoidreceptorantagonist (MRA or MCRA) or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid...
The mineralocorticoidreceptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is...
associated with type 2 diabetes. Finerenone is a non-steroidal mineralocorticoidreceptorantagonist (MRA). It is taken orally (swallowed by mouth). Common side...
potassium levels. The effects of mineralocorticoids are mediated by slow genomic mechanisms through nuclear receptors as well as by fast nongenomic mechanisms...
angiotensin receptor blockers, or angiotensin receptor-neprilysin inhibitors, along with beta blockers, mineralocorticoidreceptorantagonists and SGLT2...
treatment of hypertension. Aldosterone receptorantagonists, also known as mineralocorticoidreceptorantagonist (MRA) can lower blood pressure by blocking...
ACE inhibitors, calcium channel blockers, beta blockers, and angiotensin receptor blockers is employed, but does not have a proven benefit in HFpEF patients...
formerly known as KBP-5074, is a nonsteroidal, selective mineralocorticoidreceptorantagonist that is being developed to treat hypertension in patients...
selective aldosterone receptorantagonist (SARA). Eplerenone is more selective than spironolactone at the mineralocorticoidreceptor relative to binding...
Membrane mineralocorticoidreceptors (mMRs) or membrane aldosterone receptors are a group of receptors which bind and are activated by mineralocorticoids such...
acuity compared to control patients. Spironolactone is a mineralocorticoidreceptorantagonist that may help reduce the fluid associated with CSR. In a...
effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoidreceptorantagonist) on brain-endocrine stress responses and depression-like...
Bärfacker L (July 2017). "30 YEARS OF THE MINERALOCORTICOIDRECEPTOR: Mineralocorticoidreceptorantagonists: 60 years of research and development". The...
silent antagonist of the mineralocorticoidreceptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over...
concentrations can cross-react and activate the mineralocorticoidreceptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in...
II receptorantagonist, more often called angiotensin receptor blocker (ARB) Aldosterone receptorantagonist (mineralocorticoidreceptorantagonist, that...
MRA may refer to: Magnetic resonance angiography Mineralocorticoidreceptorantagonist Monoamine releasing agent Multiresolution analysis Madison-Ridgeland...
binding site in the nuclear receptor. These ligands are referred to as antagonists. An example of antagonistic nuclear receptor drug is mifepristone which...
Apararenone acts as a highly selective antagonist of the mineralocorticoidreceptor (Ki < 50 nM), the receptor for aldosterone. As of 2017, it is in phase...
potassium (K+) levels. It does so primarily by acting on the mineralocorticoidreceptors in the distal tubules and collecting ducts of the nephron. It...
Daiichi Sankyo Initiates Phase 3 study of CS-3150, a Novel MineralocorticoidReceptorAntagonist for Treatment of Essential Hypertension". Daiichi Sankyo...
trials: †Phase III §Never to phase III See also Glucocorticoid receptor modulators Mineralocorticoids and antimineralocorticoids List of corticosteroids...
efficacy. Categories of these modulators include receptor agonists and receptorantagonists, as well as receptor partial agonists, inverse agonists, orthosteric...
selective mineralocorticoidreceptor modulator developed by AstraZeneca for heart failure. Compared to mineralocorticoidreceptorantagonists, it is hoped...
Bärfacker L (July 2017). "30 YEARS OF THE MINERALOCORTICOIDRECEPTOR: Mineralocorticoidreceptorantagonists: 60 years of research and development". The...
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