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Mometasone information


Mometasone
Clinical data
Trade namesNasonex, Asmanex, Elocon, others[1]
Other namesLAS-41002, 9α,21-Dichloro-11β,17α-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17α-(2-furoate)
AHFS/Drugs.comMonograph
License data
  • US DailyMed: Mometasone
Pregnancy
category
  • AU: B3[2]
Routes of
administration
Topical, inhalation (nasal spray)
Drug classCorticosteroid; Glucocorticoid
ATC code
  • D07AC13 (WHO) R01AD09 (WHO), R03BA07 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[3]
  • CA: ℞-only
  • US: ℞-only / OTC[4][5]
  • EU: Rx-only[6]
Pharmacokinetic data
BioavailabilityNasal spray is virtually undetectable in plasma; but systemic availability is comparable to fluticasone[7]
Protein binding98% to 99%
MetabolismLiver
Elimination half-life5.8 hours
Identifiers
IUPAC name
  • (9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
CAS Number
  • 105102-22-5 checkY 83919-23-7
PubChem CID
  • 441335
  • as furoate: 441336
DrugBank
  • DB00764 checkY
  • as furoate: DB14512
ChemSpider
  • 390090 checkY
  • as furoate: 390091
UNII
  • 8HR4QJ6DW8
  • as furoate: 04201GDN4R
KEGG
  • D08227
  • as furoate: D00690
ChEBI
  • CHEBI:6970 checkY
  • as furoate: CHEBI:47564
ChEMBL
  • ChEMBL1201404 checkY
  • as furoate: ChEMBL1161
CompTox Dashboard (EPA)
  • DTXSID4023333 Edit this at Wikidata
ECHA InfoCard100.125.600 Edit this at Wikidata
Chemical and physical data
FormulaC22H28Cl2O4 for mometasone
C27H30O6Cl2 as furoate
3D model (JSmol)
  • Interactive image
  • as furoate: Interactive image
SMILES
  • CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)Cl)C

  • as furoate: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)OC(=O)C5=CC=CO5)C)O)Cl)C
InChI
  • InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 checkY
  • Key:QLIIKPVHVRXHRI-CXSFZGCWSA-N checkY

  • as furoate: InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
  • Key:WOFMFGQZHJDGCX-ZULDAHANSA-N
 ☒NcheckY (what is this?)  (verify)

Mometasone, also known as mometasone y 3 s, is a steroid (specifically, a glucocorticoid) medication used to treat certain skin conditions, hay fever, and asthma.[8][9][10] Specifically it is used to prevent rather than treat asthma attacks.[8] It can be applied to the skin, inhaled, or used in the nose.[8][9][10] Mometasone furoate, not mometasone, is used in medical products.[11]

Common side effects when used for asthma include asthma and thrush.[8] It is therefore recommended to rinse the mouth after use.[8] Long-term use may increase the risk for glaucoma and cataracts.[8] Common side effects when used in the nose include upper respiratory tract infections and nose bleeds.[10] Common side effects when applied on the skin include acne, skin atrophy, and itchiness.[9] It works by decreasing inflammation.[8]

Mometasone furoate was patented in 1981 and came into medical use in 1987.[12] It is on the World Health Organization's List of Essential Medicines[13] and is available as a generic medication.[14][15] In 2021, it was the 266th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[16][17]

  1. ^ Cite error: The named reference brands2016 was invoked but never defined (see the help page).
  2. ^ "Mometasone Use During Pregnancy". Drugs.com. 14 February 2020. Archived from the original on 26 October 2020. Retrieved 1 April 2020.
  3. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  4. ^ "Nasonex- mometasone furoate spray, metered". DailyMed. 26 January 2011. Archived from the original on 5 November 2022. Retrieved 19 June 2022.
  5. ^ "Nasonex- mometasone furoate spray". DailyMed. 15 December 2022. Archived from the original on 17 April 2023. Retrieved 17 April 2023.
  6. ^ "List of nationally authorised medicinal products" (PDF). European Medicines Agency. Archived (PDF) from the original on 7 March 2023. Retrieved 6 March 2023.
  7. ^ Tayab ZR, Fardon TC, Lee DK, Haggart K, McFarlane LC, Lipworth BJ, Hochhaus G (November 2007). "Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate". British Journal of Clinical Pharmacology. 64 (5): 698–705. doi:10.1111/j.1365-2125.2007.02919.x. PMC 2203259. PMID 17509041.
  8. ^ a b c d e f g "Mometasone Furoate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 7 October 2016. Retrieved 11 March 2019.
  9. ^ a b c "Mometasone Furoate topical Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 5 August 2020. Retrieved 11 March 2019.
  10. ^ a b c "Mometasone Furoate eent Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 30 April 2016. Retrieved 11 March 2019.
  11. ^ "Mometasone". DrugBank. Archived from the original on 29 June 2019. Retrieved 30 April 2020.
  12. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 488. ISBN 9783527607495.
  13. ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  14. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  15. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 265. ISBN 9780857113382.
  16. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  17. ^ "Mometasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.

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Mometasone

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Mometasone, also known as mometasone y 3 s, is a steroid (specifically, a glucocorticoid) medication used to treat certain skin conditions, hay fever,...

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Topical steroid

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25% (Topicort) Triamcinolone acetonide 0.5% (Kenalog, Aristocort cream) Mometasone furoate 0.1% (Elocon, Elocom ointment) Fluticasone propionate 0.005% (Cutivate)...

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Formoterol

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also marketed in the combination formulations budesonide/formoterol and mometasone/formoterol. In November 2005, the US Food and Drug Administration (FDA)...

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Dimetindene

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GR, Dowdee AM (September 2008). "Assessment of Patient Attitudes About Mometasone Furoate Nasal Spray: The Ease-of-Use Patient Survey". The World Allergy...

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Corticosteroid

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Beclometasone, betamethasone, dexamethasone, fluocortolone, halometasone, and mometasone. Alclometasone dipropionate, betamethasone dipropionate, betamethasone...

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Nasal spray

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Budesonide Ciclesonide Flunisolide Fluticasone furoate Fluticasone propionate Mometasone Triamcinolone acetonide Saline sprays are typically non medicated. A mist...

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Decongestant

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Azelastine/fluticasone (Dymista) – also an antihistamine via azelastine Mometasone furoate (Nasonex) Prednisolone Tixocortol (Pivalone) Triamcinolone (Nasacort)...

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ATC code R03

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budesonide R03AK08 Formoterol and beclometasone R03AK09 Formoterol and mometasone R03AK10 Vilanterol and fluticasone furoate R03AK11 Formoterol and fluticasone...

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Adenoid hypertrophy

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nasal obstruction. There is some low-quality evidence suggesting that mometasone may lead to symptomatic improvement in children with adenoid hypertrophy...

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Steroid eluting sinus stent

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They are, however, of unclear benefit as of 2015. One version releases mometasone furoate. It is a bioabsorbable steroid-eluting stent. It delivers steroids...

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List of medical inhalants

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Budesonide Ciclesonide Cromolyn Dexamethasone Flunisolide Fluticasone Mometasone Nedocromil Triamcinolone Pentamidine Ribavirin Tobramycin Zanamivir Beractant...

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Abediterol

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clinical trials, but was discontinued in 2021. Its coformulation with mometasone furoate also progressed to Phase II clinical trials, but was discontinued...

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Glenmark Pharmaceuticals

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allergic rhinitis (SAR). Ryaltris (olopatadine hydrochloride [665 mcg] and mometasone furoate [25 mcg]), formerly GSP 301 Nasal Spray, has been conditionally...

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Dexamethasone

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Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene Rimexolone Triamcinolone Ulobetasol...

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WHO Model List of Essential Medicines

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mometasone are alternatives Beclometasone/formoterol, budesonide/salmeterol, fluticasone/formoterol, fluticasone furoate/vilanterol, and mometasone/formoterol...

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Methasone

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desoximetasone, dexamethasone, flumetasone, halometasone, icometasone, mometasone, and paramethasone, among others. Fluprednidene and prednylidene are corticosteroids...

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Chlorine gas poisoning

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"Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide". Toxicology and Applied Pharmacology. 272 (2). Elsevier...

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Lichen sclerosus

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mild and moderate cases. For severe cases, it has been theorized that mometasone furoate might be safer and more effective than clobetasol. Recent studies...

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Fluticasone propionate

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Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene Rimexolone Triamcinolone Ulobetasol...

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Allergic rhinitis

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with time.[citation needed] In 2013, a study compared the efficacy of mometasone furoate nasal spray to betamethasone oral tablets for the treatment of...

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Steroid

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Meprednisone hydrogen succinate (methylprednisone hemisuccinate) Mometasone Mometasone furoate Paramethasone Paramethasone acetate Paramethasone disodium...

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Cortisol

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Meprednisone hydrogen succinate (methylprednisone hemisuccinate) Mometasone Mometasone furoate Paramethasone Paramethasone acetate Paramethasone disodium...

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ATC code R01

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R01AD06 Betamethasone R01AD07 Tixocortol R01AD08 Fluticasone R01AD09 Mometasone R01AD11 Triamcinolone R01AD12 Fluticasone furoate R01AD13 Ciclesonide...

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Spironolactone

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acetate Fludrocortisone (fludrocortone) Fludrocortisone acetate Mometasone Mometasone furoate Prednisolone Prednazate Prednazoline Prednicarbate (prednisolone...

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Asthma

Last Update:

exacerbations. Commonly used corticosteroids are budesonide, fluticasone, mometasone and ciclesonide. Long-acting beta-adrenoceptor agonists (LABA) such as...

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