Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Methionine sulfoximine (MSO, also known as MetSox[1]) is an irreversible glutamine synthetase inhibitor. It is the sulfoximine derivative of methionine with convulsant effects.[2]
Methionine sulfoximine is composed of two different diastereomers, which are L-S-Methionine sulfoximine and L-R-Methionine sulfoximine. These affect the longevity of the model mouse for Lou Gehrig's disease.[3] Overproduction of glutamate results to excitotoxicity, which kills the cell. Since methionine sulfoximine inhibits glutamate production in the brain, it prevents excitotoxicity. Thus, increasing the longevity of the mice.[4]
^Carroll, P.; Waddell, S. J.; Butcher, P. D.; Parish, T. (2011). "Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1". Microbial Drug Resistance. 17 (3): 351–355. doi:10.1089/mdr.2010.0125. PMC 3161625. PMID 21875360.
^Rowe, WB; Meister, A (June 1970). "Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine". Proceedings of the National Academy of Sciences of the United States of America. 66 (2): 500–6. Bibcode:1970PNAS...66..500R. doi:10.1073/pnas.66.2.500. PMC 283073. PMID 4393740.
^Brusilow, William S. A. (2017-04-24). "Identification of the isomer of methionine sulfoximine that extends the lifespan of the SOD1 G93A mouse". Neuroscience Letters. 647: 165–167. doi:10.1016/j.neulet.2017.03.029. ISSN 0304-3940. PMID 28323087. S2CID 45664203.
^Bame, Monica; Pentiak, Patricia A.; Needleman, Richard; Brusilow, William S. A. (2012-12-01). "Effect of Sex on Lifespan, Disease Progression, and the Response to Methionine Sulfoximine in the SOD1 G93A Mouse Model for ALS". Gender Medicine. 9 (6): 524–535. doi:10.1016/j.genm.2012.10.014. ISSN 1550-8579. PMID 23217569.
and 27 Related for: Methionine sulfoximine information
Methioninesulfoximine (MSO, also known as MetSox) is an irreversible glutamine synthetase inhibitor. It is the sulfoximine derivative of methionine with...
while low concentrations should activate GS activity. Inhibitors: Methioninesulfoximine (MSO): MSO is an inhibitor that binds to the glutamate site. Bound...
class of compounds is derived from the discovery that methionine sulfoximide (methioninesulfoximine) is an inhibitor of glutamine synthetase. Sulfonediimines...
to several amino acids, including four that are essential for humans: methionine, threonine, isoleucine, and lysine. The conversion of aspartate to these...
conjunction with a rapid rise in ammonia levels. Toxic exposures to methioninesulfoximine, cuprizone, isoniazid, triethyltin, hexachlorophene, and hydrogen...
Salber D, et al. (2006). "Differential uptake of [18F]FET and [3H]l-methionine in focal cortical ischemia". Nuclear Medicine and Biology. 33 (8): 1029–1035...
a vehicle for promoting mental-skill games Mind Sports Olympiad Methioninesulfoximine, a chemical compound Multiple system operator, an operator of multiple...
include S,S-diphenylsulfilimine and sulfoximines [Category] such as methylphenylsulfoximine: In the case of a sulfoximine, the bonds can be considered single...
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