Cycloserine, sold under the brand name Seromycin, is a GABA transaminase inhibitor and an antibiotic, used to treat tuberculosis.[1][2] Specifically it is used, along with other antituberculosis medications, for active drug resistant tuberculosis.[2] It is given by mouth.[2]
Common side effects include allergic reactions, seizures, sleepiness, unsteadiness, and numbness.[2] It is not recommended in people who have kidney failure, epilepsy, depression, or are alcoholics.[2] It is unclear if use during pregnancy is safe for the baby.[2] Cycloserine is similar in structure to the amino acid D-alanine and works by interfering with the formation of the bacteria's cell wall.[2]
Cycloserine was discovered in 1954 from a type of Streptomyces.[3] It is on the World Health Organization's List of Essential Medicines.[4]
^Polc P, Pieri L, Bonetti EP, Scherschlicht R, Moehler H, Kettler R, et al. (April 1986). "L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats". Neuropharmacology. 25 (4). Elsevier BV: 411–418. doi:10.1016/0028-3908(86)90236-4. PMID 3012401. S2CID 462885.
^ abcdefg"Cycloserine". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
^Gottlieb D, Shaw PD (2012). Mechanism of Action. Springer Science & Business Media. p. 41. ISBN 9783642460517. Archived from the original on 2016-12-20.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Cycloserine, sold under the brand name Seromycin, is a GABA transaminase inhibitor and an antibiotic, used to treat tuberculosis. Specifically it is used...
cynophobia. There are no medications designed to treat ailurophobia. D-cycloserine has been linked to facilitating better results in exposure therapy. List...
forgetting. D-cycloserine is a chemical which enhances (agonist) the activity of the NMDA receptors. When used in rats, D-cycloserine was shown to produce...
for anxiety disorders is extinction learning. Hofmann has shown that d-cycloserine, a partial agonist of the glutamate receptor can augment extinction learning...
(MDR-TB) in conjunction with other second-line drugs. It is a derivate of cycloserine and it is bacteriostatic. Galietti F, Giorgis GE, Oliaro A, Boaro D,...
metabolize to it, such as phenelzine), ethanolamine-O-sulfate (EOS), and L-cycloserine. Certain members of this class are used as anticonvulsants. Ciesielski...
suggesting that adjuvant use of the NMDA receptor partial agonist, d-cycloserine, with virtual reality exposure therapy may improve specific phobia symptoms...
mitochondrial membrane protein, impairs mitochondrial respiration), cycloserine, and linezolid. Ringed sideroblasts are seen in the bone marrow. On the...
neurochemical recovery must be addressed. The author noted that oxytocin and D-cycloserine are potentially safer co-drugs in PTSD treatment, albeit with limited...
research. It has been shown that a combination of acute dosing of d-cycloserine (DCS) with exposure therapy facilitates the effects of exposure therapy...
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