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A metabolic network is the complete set of metabolic and physical processes that determine the physiological and biochemical properties of a cell. As such, these networks comprise the chemical reactions of metabolism, the metabolic pathways, as well as the regulatory interactions that guide these reactions.
With the sequencing of complete genomes, it is now possible to reconstruct the network of biochemical reactions in many organisms, from bacteria to human. Several of these networks are available online:
Kyoto Encyclopedia of Genes and Genomes (KEGG),[1] EcoCyc,[2] BioCyc[3] and metaTIGER.[4]
Metabolic networks are powerful tools for studying and modelling metabolism.
Carbon fixation
Photo- respiration
Pentose phosphate pathway
Citric acid cycle
Glyoxylate cycle
Urea cycle
Fatty acid synthesis
Fatty acid elongation
Beta oxidation
Peroxisomal
beta oxidation
Glyco- genolysis
Glyco- genesis
Glyco- lysis
Gluconeo- genesis
Pyruvate decarb- oxylation
Fermentation
Keto- lysis
Keto- genesis
feeders to gluconeo- genesis
Direct / C4 / CAM carbon intake
Light reaction
Oxidative phosphorylation
Amino acid deamination
Citrate shuttle
Lipogenesis
Lipolysis
Steroidogenesis
MVA pathway
MEP pathway
Shikimate pathway
Transcription & replication
Translation
Proteolysis
Glycosyl- ation
Sugar acids
Double/multiple sugars & glycans
Simple sugars
Inositol-P
Amino sugars & sialic acids
Nucleotide sugars
Hexose-P
Triose-P
Glycerol
P-glycerates
Pentose-P
Tetrose-P
Propionyl -CoA
Succinate
Acetyl -CoA
Pentose-P
P-glycerates
Glyoxylate
Photosystems
Pyruvate
Lactate
Acetyl -CoA
Citrate
Oxalo- acetate
Malate
Succinyl -CoA
α-Keto- glutarate
Ketone bodies
Respiratory chain
Serine group
Alanine
Branched-chain amino acids
Aspartate group
Homoserine group & lysine
Glutamate group & proline
Arginine
Creatine & polyamines
Ketogenic & glucogenic amino acids
Amino acids
Shikimate
Aromatic amino acids & histidine
Ascorbate (vitamin C)
δ-ALA
Bile pigments
Hemes
Cobalamins (vitamin B12)
Various vitamin Bs
Calciferols (vitamin D)
Retinoids (vitamin A)
Quinones (vitamin K) & tocopherols (vitamin E)
Cofactors
Vitamins & minerals
Antioxidants
PRPP
Nucleotides
Nucleic acids
Proteins
Glycoproteins & proteoglycans
Chlorophylls
MEP
MVA
Acetyl -CoA
Polyketides
Terpenoid backbones
Terpenoids & carotenoids (vitamin A)
Cholesterol
Bile acids
Glycero- phospholipids
Glycerolipids
Acyl-CoA
Fatty acids
Glyco- sphingolipids
Sphingolipids
Waxes
Polyunsaturated fatty acids
Neurotransmitters & thyroid hormones
Steroids
Endo- cannabinoids
Eicosanoids
Major metabolic pathways in metro-style map. Click any text (name of pathway or metabolites) to link to the corresponding article. Single lines: pathways common to most lifeforms. Double lines: pathways not in humans (occurs in e.g. plants, fungi, prokaryotes). Orange nodes: carbohydrate metabolism. Violet nodes: photosynthesis. Red nodes: cellular respiration. Pink nodes: cell signaling. Blue nodes: amino acid metabolism. Grey nodes: vitamin and cofactor metabolism. Brown nodes: nucleotide and protein metabolism. Green nodes: lipid metabolism.
^"GenomeNet". www.genome.ad.jp. Archived from the original on 2009-02-24. Retrieved 2020-04-01.
^"EcoCyc: Encyclopedia of E. coli Genes and Metabolic Pathways". www.ecocyc.org.
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