Merkel cells (shown in blue) are located in the basal epidermal layer of the skin.
Details
Location
Skin of vertebrates
Function
Light touch sensation
Identifiers
MeSH
D018862
NeuroLex ID
nifext_87
Anatomical terms of neuroanatomy
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Merkel cells, also known as Merkel-Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and found in the skin of vertebrates. They are abundant in highly sensitive skin like that of the fingertips in humans, and make synaptic contacts with somatosensory afferent nerve fibers. It has been reported that Merkel cells are derived from neural crest cells, though more recent experiments in mammals have indicated that they are epithelial in origin.
Merkelcells, also known as Merkel-Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for light touch sensation and...
Merkelcell polyomavirus (MCV or MCPyV) was first described in January 2008 in Pittsburgh, Pennsylvania. It was the first example of a human viral pathogen...
position, and deep static touch features, such as shapes and edges. Merkelcells in the basal epidermis of the skin store serotonin which they release...
but a recently discovered analogue called Merkelcell polyomavirus has been associated with Merkelcell carcinoma, a form of skin cancer. The Rb binding...
virus with progressive multifocal leukoencephalopathy, and Merkelcell virus with Merkelcell cancer. Polyomaviruses are non-enveloped double-stranded DNA...
susceptible to viral infections. Indeed, footprints of JC polyomavirus and Merkelcell polyomavirus have been detected in PBMCs from pregnant women and women...
brand name Zynyz, is an anti-cancer medication used for the treatment of Merkelcell carcinoma. Retifanlimab is a programmed death receptor-1 (PD-1)–blocking...
monoclonal antibody medication for the treatment of Merkelcell carcinoma, urothelial carcinoma, and renal cell carcinoma. Common side effects include fatigue...
After entering a cell, it is ready to be translated into viral proteins, wrapped in the cell's lipid envelope, and sent out of the cell as a newly made...
A (IgA) antibodies; IgG antibodies persist for life and confer immunity. Cell-mediated immune responses are also important in limiting the scope and the...
which comprise 90% of its cells, but also contains melanocytes, Langerhans cells, Merkelcells,: 2–3 and inflammatory cells. Epidermal thickenings called...
age 76, at his home in Sag Harbor, New York, due to complications from Merkel-cell carcinoma, a rare and aggressive skin cancer, with which he had been...
T-lymphotropic virus 1, Kaposi's sarcoma-associated herpesvirus and Merkelcell polyomavirus. Human immunodeficiency virus (HIV) does not directly cause...
chickenpox has resolved, the virus can remain dormant (inactive) in human nerve cells (dorsal root ganglia or cranial nerves) for years or decades, after which...
facilitating the entry of parvovirus B19 into the host cell. After gaining access to the host cell, B19V binds to glycosphingolipid globoside (blood group...
after carbon dioxide laser treatment. Keratolysis, of dead surface skin cells usually using salicylic acid, blistering agents, immune system modifiers...
impacting pregnancy outcome. In addition, footprints of JC polyomavirus and Merkelcell polyomavirus have been detected in chorionic villi from females affected...
Henderson-Patterson bodies) in the epidermis, above the stratum basale, which consist of cells with abundant large granular eosinophilic cytoplasmic inclusion bodies (accumulated...
identified. Included were several herpesviruses, hepatitis B virus, Merkelcell polyomavirus, and human papillomavirus 31. Given the reactivation and/or...
infection, the viruses are transported along sensory nerves to the nerve cell bodies, where they reside lifelong. Causes of recurrence may include: decreased...
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