Menthyl isovalerate information

Menthyl isovalerate
Names
	IUPAC name (1R,3R,4S)-p-Menthan-3-yl 3-methylbutanoate
	Systematic IUPAC name (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 3-methylbutanoate
	Other names Validolum; Valofin; Validol; Menthoval
Identifiers
CAS Number	28221-20-7 ;
3D model (JSmol)	Interactive image;
ChemSpider	107053;
ECHA InfoCard	100.036.766
PubChem CID	119900;
UNII	P5M0O284O6 ;
CompTox Dashboard (EPA)	DTXSID00861678 ;
	InChI InChI=1S/C15H28O2/c1-10(2)8-15(16)17-14-9-12(5)6-7-13(14)11(3)4/h10-14H,6-9H2,1-5H3/t12-,13+,14-/m1/s1 Key: VYQSSWZYPCCBRN-HZSPNIEDSA-N; InChI=1/C15H28O2/c1-10(2)8-15(16)17-14-9-12(5)6-7-13(14)11(3)4/h10-14H,6-9H2,1-5H3/t12-,13+,14-/m1/s1 Key: VYQSSWZYPCCBRN-HZSPNIEDBT;
	SMILES C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)CC(C)C)C(C)C;
Properties
Chemical formula	C15H28O2
Molar mass	240.387 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Menthyl isovalerate, also known as validolum, is the menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in ethanol, while practically insoluble in water. It is used as a food additive for flavor and fragrance.^[1]

Validol, the anxiety medication containing a roughly 25% solution of menthol in menthyl isovalerate is prepared essentially in one step, in which the amount of menthol added before conducting the acid catalysed esterification is in an excess such that the resulting solution of the yielded ester has around 25% menthol, simplifying the procedure. Work up might consist of several washings, including one with aqueous sodium bicarbonate to neutralize traces of acid catalyst and unreacted isovaleric acid, and distillation.^{[citation needed]}

^ Menthyl isovalerate.

[1] Menthyl isovalerate.

Menthyl isovalerate information

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Menthyl isovalerate

Anxiolytic

Menthol

Ethchlorvynol

Methaqualone

Nicotinamide

Butalbital

Bromazolam

Ivermectin

Hopantenic acid

Chloral hydrate

Triazolam

Lorazepam

Dichloromethane

Flunitrazepam

Nitrazepam

Chlordiazepoxide

Etomidate

Isopropyl alcohol

Cholesterol

Carisoprodol

Nonbenzodiazepine

Secobarbital

Benzene

Chlorobutanol

Amobarbital

Barbital

Butane