The mdx mouse is a popular model for studying Duchenne muscular dystrophy (DMD).[1][2] The mdx mouse has a point mutation in its DMD gene, changing the amino acid coding for a glutamine to STOP codon. This causes the muscle cells to produce a small, nonfunctional dystrophin protein.[3] As a result, the mouse has a mild form of DMD where there is increased muscle damage and weakness.
^McArdle, Anne. (1993). Mechanisms skeletal muscle damage in the dystrophin-deficient MDX mouse (PhD thesis). University of Liverpool. OCLC 53496566. EThOS uk.bl.ethos.385144.
^Bulfield, G.; Siller, W. G.; Wight, P. A.; Moore, K. J. (1984). "X chromosome-linked muscular dystrophy (mdx) in the mouse". Proceedings of the National Academy of Sciences of the United States of America. 81 (4): 1189–1192. Bibcode:1984PNAS...81.1189B. doi:10.1073/pnas.81.4.1189. PMC 344791. PMID 6583703.
The mdxmouse is a popular model for studying Duchenne muscular dystrophy (DMD). The mdxmouse has a point mutation in its DMD gene, changing the amino...
eXpressions, a query language for OLAP databases Acura MDX, a sport utility vehicle introduced by Honda Mdxmouse, a popular model for studying Duchenne muscular...
include the mdxmouse, GRMD (golden retriever muscular dystrophy) dog, and HFMD (hypertrophic feline muscular dystrophy) cat. The mdxmouse contains a...
2007). "Intrinsic laryngeal muscles are spared from myonecrosis in the mdxmouse model of Duchenne muscular dystrophy". Muscle & Nerve. 35 (3): 349–353...
longevity for people with Duchenne muscular dystrophy. Curiously, in the mdxmouse model of Duchenne muscular dystrophy, the lack of dystrophin is associated...
placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdxmouse: cardiac protection and improved exercise performance". European Heart...
"Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdxmouse, a model for Duchenne muscular dystrophy". British Journal of Pharmacology...
Liverpool in 1988 and completed her PhD studying muscle damage using the mdxmouse model of Duchenne muscular dystrophy. McArdle undertook postdoctoral training...
J. (2009). Laminin-111 protein therapy prevents muscle disease in the mdxmouse model for Duchenne muscular dystrophy. Proceedings of the National Academy...
reported two prostate cancer patients involved in a phase II study using MDX-010 therapy who had been told initially that their condition was inoperable...
"Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdxmouse, a model for Duchenne muscular dystrophy". British Journal of Pharmacology...
allow for the use of MDX in indications that require a longer therapeutic window, such as cognitive impairment-related disorders. MDX has demonstrated significant...
Davies KE (September 2000). "Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice". Mamm....
currently already approved for the treatment of paracetamol overdose. In mousemdx models of Duchenne's muscular dystrophy, treatment with 1–2% acetylcysteine...
the C# programming language. This API was known as "Managed DirectX" (or MDX for short), and claimed to operate at 98% of performance of the underlying...
amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse". Nature Medicine. 9 (8): 1009–1014. doi:10.1038/nm897 – via www...
paper, the engine may seem to be the same unit as shared with the Acura MDX, it is actually a variant that introduces, for the first time ever on an...
The Oxford Medical Group, P.C. and chief executive officer and chair of MDx Med-Care. In 1991 Straus took a poetry workshop at the 92nd Street Y in New...
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