Fab fragment of ipilimumab (blue) binding CTLA-4 (green). From PDB entry 5TRU.
Monoclonal antibody
Type
Whole antibody
Source
Human
Target
CTLA-4
Clinical data
Pronunciation
i pi lim′ ue mab
Trade names
Yervoy
Other names
BMS-734016,[1] MDX-010,[2] MDX-101
AHFS/Drugs.com
Monograph
MedlinePlus
a611023
License data
US DailyMed: Ipilimumab
Pregnancy category
AU: C
Routes of administration
Intravenous (IV)
ATC code
L01FX04 (WHO)
Legal status
Legal status
AU: S4 (Prescription only)
CA: ℞-only /Schedule D[3]
UK: POM (Prescription only)[4]
US: ℞-only[5]
EU: Rx-only[6]
In general: ℞ (Prescription only)
Identifiers
CAS Number
477202-00-9N
DrugBank
DB06186Y
ChemSpider
none
UNII
6T8C155666
KEGG
D04603Y
ChEMBL
ChEMBL1789844
Chemical and physical data
Formula
C6742H9972N1732O2004S40
Molar mass
148634.46 g·mol−1
NY (what is this?)(verify)
Ipilimumab, sold under the brand name Yervoy, is a monoclonal antibody medication that works to activate the immune system by targeting CTLA-4, a protein receptor that downregulates the immune system.
Cytotoxic T lymphocytes (CTLs) can recognize and destroy cancer cells. However, an inhibitory mechanism interrupts this destruction.[7] Ipilimumab turns off this inhibitory mechanism and boosts the body's immune response against cancer cells.[7][8]
Ipilimumab was approved by the US Food and Drug Administration (FDA) in March 2011, for the treatment of melanoma, renal cell carcinoma (RCC), colorectal cancer, hepatocellular carcinoma, non-small cell lung cancer (NSCLC), malignant pleural mesothelioma, esophageal cancer.[9][10][11][12] It is undergoing[when?] clinical trials for the treatment of bladder cancer[13] and metastatic hormone-refractory prostate cancer.[14]
The concept of using anti-CTLA4 antibodies to treat cancer was first developed by James P. Allison while he was director of the Cancer Research Laboratory at the University of California, Berkeley.[15][16] Clinical development of anti-CTLA4 was initiated by Medarex, which was later acquired by Bristol-Myers Squibb. For his work in developing ipilimumab, Allison was awarded the Lasker Award in 2015.[17] Allison later was the co-winner of the 2018 Nobel Prize in Physiology or Medicine.[18]
^USAN. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab" (Press release). American Medical Association (AMA). Archived from the original on 2016-02-23. Retrieved 2013-01-12.
^"Regulatory Decision Summary for Yervoy". Drug and Health Products Portal. 7 December 2023. Retrieved 2 April 2024.
^"Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 3 August 2020. Retrieved 2 October 2020.
^"Yervoy- ipilimumab injection". DailyMed. 13 August 2020. Retrieved 2 October 2020.
^"Yervoy EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 2 October 2020.
^ abSyn NL, Teng MW, Mok TS, Soo RA (December 2017). "De-novo and acquired resistance to immune checkpoint targeting". The Lancet. Oncology. 18 (12): e731–e741. doi:10.1016/s1470-2045(17)30607-1. PMID 29208439.
^Cite error: The named reference Ribas was invoked but never defined (see the help page).
^"Yervoy". Opdivo. Bristol Myers Squibb. Retrieved 7 February 2024.
^"Drug Approval Package: Yervoy (ipilimumab) Injection NDA #125377". U.S. Food and Drug Administration (FDA). 24 December 1999. Retrieved 2 October 2020.
^Lacroix M (2014). Targeted Therapies in Cancer. Hauppauge, NY: Nova Sciences Publishers. ISBN 978-1-63321-687-7. Archived from the original on 2015-06-26. Retrieved 2014-07-13.
^Pollack A (May 29, 2015). "New Class of Drugs Shows More Promise in Treating Cancer". New York Times. Retrieved May 30, 2015.
^Clinical trial number NCT01524991 for "First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma" at ClinicalTrials.gov (completed)
^Clinical trial number NCT00323882 for "Phase I/II Study of MDX-010 in Patients With Metastatic Hormone-Refractory Prostate Cancer (MDX010-21)" at ClinicalTrials.gov (completed)
^"UC Berkeley Cancer Research Lab » The Story of Yervoy (Ipilimumab)". crl.berkeley.edu.
^Lasker Foundation. "Deep brain stimulation for Parkinson's disease". The Lasker Foundation.
^"The Nobel Prize in Physiology or Medicine 2018 to James P. Allison and Tasuku Honjo". Archived from the original on 2018-12-24. Retrieved 2018-10-01.
Ipilimumab, sold under the brand name Yervoy, is a monoclonal antibody medication that works to activate the immune system by targeting CTLA-4, a protein...
first-line treatment for inoperable or metastatic melanoma in combination with ipilimumab if the cancer does not have a mutation in BRAF, and as a second-line treatment...
group using the vaccine, 44% in the vaccine and ipilimumab group, and 46% in the group treated with ipilimumab alone. However, some have raised concerns about...
function. The first anti-cancer drug targeting an immune checkpoint was ipilimumab, a CTLA4 blocker approved in the United States in 2011. Currently approved...
immune function. Approved checkpoint inhibitors include antibodies such as ipilimumab, nivolumab, and pembrolizumab. Dendritic cell therapy provokes anti-tumor...
Program. It is approved for use following treatment with ipilimumab, or after treatment with ipilimumab and a BRAF inhibitor in advanced melanoma patients who...
Treatment with pembrolizumab, atezolizumab, or combination nivolumab plus ipilimumab are all superior to chemotherapy alone against tumors expressing PD-L1...
chemotherapy. In the context of melanoma, certain treatments, such as Ipilimumab, result in high grade adverse events, or immune-related adverse events...
there are now multiple generic producers. Vumon (teniposide) Yervoy (ipilimumab) Psychiatry Abilify (aripiprazole comarketed with Otsuka Pharmaceutical)...
antibody. Nivolumab and Pembrolizumab are anti PD-1 monoclonal antibodies. Ipilimumab is a monoclonal antibody that targets Cytotoxic T-lymphocyte-associated...
Therapies for metastatic melanoma include the biologic immunotherapy agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and...
century, the clinical use of immune checkpoint blocking antibodies such as ipilimumab or pembrolizumab has greatly increased the number of abscopally responding...
Therapies for metastatic melanoma include the biologic immunotherapy agents ipilimumab, pembrolizumab, and nivolumab; BRAF inhibitors, such as vemurafenib and...
Treatments for metastatic melanoma include biologic immunotherapy agents ipilimumab, pembrolizumab, nivolumab, cemiplimab; BRAF inhibitors, such as vemurafenib...
"Immunization Strategy With Intra-tumoral Injections of Pexa-Vec With Ipilimumab in Metastatic / Advanced Solid Tumors". ClinicalTrials.gov. Retrieved...
Cephem-type antibiotics cefazolin -mab Monoclonal antibodies trastuzumab, ipilimumab -ximab Chimeric antibody, in which the design of the therapeutic antibody...
effects. When compared with combinations of immunotherapy (nivolumab and ipilimumab), sunitinib may lead to more progression and serious effects. There may...
recently, the FDA has approved a combination therapy with both anti-CTLA4 (ipilimumab) and anti-PD1 (nivolumab) in October 2015. The molecular factors and receptors...
Howerver, the KEYNOTE-598 phase III trial has reported in 2021 that adding ipilimumab to pembrolizumab for NSCLC patients with PD-L1 tumor proportion score...
ClinicalTrials.gov. 2 June 2020. Retrieved 7 August 2020. "A Study of REGN2810 and Ipilimumab in Patients With Lung Cancer". ClinicalTrials.gov. 12 February 2018. Retrieved...