A schematic diagram of the structure of laminin 111 and several hypothesized binding sites of cell-surface receptors.[1]
Laminin–111 (also "laminin–1") is a protein of the type known as laminin isoforms. It was among the first of the laminin isoforms to be discovered.[2] The "111" identifies the isoform's chain composition of α1β1γ1.[2] This protein plays an important role in embryonic development. Injections of this substance are used in treatment for Duchenne muscular dystrophy, and its cellular action may potentially become a focus of study in cancer research.
^Colognato, H., & Yurchenco, P. D. (2000). Form and function: The laminin family of heterotrimers. Developmental Dynamics, 218(2): 213-234.
^ abAumailley, M., Bruckner-Tuderman, L., Carter, W. G., Deutzmann, R., Edgar, D., Ekblom, P., & Yurchenco, P. D. (2005). A simplified laminin nomenclature. Matrix biology, 24(5): 326-332.
Laminin–111 (also "laminin–1") is a protein of the type known as laminin isoforms. It was among the first of the laminin isoforms to be discovered. The...
laminin-1, laminin-2, laminin-3, etc., but the nomenclature was changed to describe which chains are present in each isoform (laminin-111, laminin-211...
cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. Laminins, a family of extracellular matrix glycoproteins...
adhesion to laminin 1 or 5 induces isoform-specific clustering of integrins and other focal adhesion components" (PDF). Journal of Cell Science. 111 (6): 793–802...
scarring. Malignancy — MMP with antibodies directed against laminin 332 (previously known as laminin 5 and epiligrin) has been associated with an increased...
with extracellular matrix proteins, including collagen, fibronectin, and laminin, during migration. Once the basal lamina becomes permeable the neural crest...
also containing a P component, apolipoprotein, collagen, fibronectin, and laminin. The P component, a pentameric protein, stabilizes the fibrils of the amyloid...
between the two.: 1511 As such, type IV OI is often termed "variable" OI,: 111 with the severity of even those in the same family (so, with the same genetic...
molecules like laminin and proteoglycans. In addition to collagen IV, the epidermal and endothelial basement membrane also contains laminin, perlecan and...
the virion associates with putative receptors such as alpha integrins, laminins, and annexin A2 leading to entry of the virions into basal epithelial cells...
matrices (ECM). In the late 1980s, Bissell and colleagues showed that a laminin rich gel can be used as a basement membrane for differentiation and morphogenesis...
of the devices with proteins that encourage neuron attachment, such as laminin, or drug eluting substances. The nature of dissociated neuronal networks...
to form tissues and specific regions of those tissues. Fibronectin and laminin both play a role in adrenocyte mutation into distinctive distribution in...
"Induction of cytotoxic T-cell responses against the oncofetal antigen-immature laminin receptor for the treatment of hematologic malignancies". Blood. 102 (13):...
dystrophies including CMD Type 1 A (CMD 1A) caused by mutation in the human laminin α2 (LAMA2) gene. The zebrafish, because of its advantages discussed above...
understood. Laminin, a component of the extracellular matrix, plays an important role in regulating oligodendrocyte production. Mice lacking laminin alpha2-subunit...
hydrophobicity, showing successful modification of the surface via the laminin protein. The laminin immobilized surface promotes the attachment and growth of the...
glycoprotein that defines the Lutheran blood group and also known as Lu or laminin-binding protein. Structural role – The following membrane proteins establish...
Hertzler, PL; McClay, DR (1999). "alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo". Developmental Biology. 207 (1): 1–13. doi:10...
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