negative regulation of activin receptor signaling pathway
negative regulation of transcription by RNA polymerase II
hematopoietic progenitor cell differentiation
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10468
14313
Ensembl
ENSG00000134363
ENSMUSG00000021765
UniProt
P19883
P47931
RefSeq (mRNA)
NM_006350 NM_013409
NM_008046 NM_001301373 NM_001301375
RefSeq (protein)
NP_006341 NP_037541
NP_001288302 NP_001288304 NP_032072
Location (UCSC)
Chr 5: 53.48 – 53.49 Mb
Chr 13: 114.59 – 114.6 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene.[5][6] Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.[6]
Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone.
An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).
^ abcGRCh38: Ensembl release 89: ENSG00000134363 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021765 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ueno N, Ling N, Ying SY, Esch F, Shimasaki S, Guillemin R (December 1987). "Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America. 84 (23): 8282–8286. Bibcode:1987PNAS...84.8282U. doi:10.1073/pnas.84.23.8282. PMC 299526. PMID 3120188.
^ abTortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL (August 2001). "Human follistatin-related protein: a structural homologue of follistatin with nuclear localization". Endocrinology. 142 (8): 3426–3434. doi:10.1210/endo.142.8.8319. PMID 11459787.
Follistatin, also known as activin-bindings protein, is a protein that in humans is encoded by the FST gene. Follistatin is an autocrine glycoprotein that...
insulin resistance, cardiovascular disease, and chronic kidney disease. Follistatin is an endogenous protein that negatively regulates myostatin. Reduction...
Follistatin like 5 is a protein that in humans is encoded by the FSTL5 gene. GRCh38: Ensembl release 89: ENSG00000168843 – Ensembl, May 2017 GRCm38: Ensembl...
which elevate blood pressure. In the reproductive system, inhibins and follistatin counterregulate activins, to control follicle-stimulating hormone and...
Follistatin-related protein 1 is a protein that in humans is encoded by the FSTL1 gene. This gene encodes a protein with similarity to follistatin, an...
mammals or GnIH in avian species to inhibit GnRH. The hypothalamus uses follistatin to tell the pituitary to inhibit follicle-stimulating hormone; it also...
Mississippi, United States Fixation index (FST), in population genetics Follistatin, a mammalian glycoprotein (and gene) Franciscan School of Theology, in...
Follistatin-related protein 3 is a protein that in humans is encoded by the FSTL3 gene. Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein...
Animals lacking myostatin or animals treated with substances such as follistatin that block the binding of myostatin to its receptor have significantly...
of gene expression show that a specific complement of genes, such as follistatin and multiple cyclin kinase inhibitors are involved in ovarian development...
neural tissue. Follistatin was identified as a TGF-β inhibitor, and it was later shown that chordin and noggin both work alongside follistatin to inhibit...
GDF6 and GDF7. Follistatin inhibits Activin, which it binds. It directly affects follicle-stimulating hormone (FSH) secretion. Follistatin also is implicated...
protein, and a requirement for “inhibitory signals” such as noggin and follistatin. Even before the term induction was popularized, several authors, beginning...
which is negatively regulated by myostatin. We also found Myod1 and follistatin to be increased in response to decorin overexpression. Moreover, muscle-specific...
differentiate through molecules that induce differentiation including follistatin, fibroblast growth factors, and activation of the Notch receptor system...
cause is thought to be a defect in the interactions between activin, follistatin and TGF-β, leading to a developmental disorder of glandular tissue. Surgical...
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 is a protein that in humans is encoded by the WFIKKN2 gene. The WFIKKN1...
in vivo studies include β-lactam antibiotics (e.g., ceftriaxone) and follistatin. This approach aims to counter the effect of SMA by targeting the muscle...
encoding protein FRY like transcription coactivator FSTL5: encoding protein Follistatin like 5 GUF1: GUF1 homolog, GTPase HDL3: encoding Huntington-like neurodegenerative...
Subject Headings (MeSH) Grusch M, Kreidl E (1 August 2008). "Activin and follistatin in liver biology and hepatocellular carcinoma". SciTopics. Elsevier....
Kazal-type serine protease inhibitor domain the structure of the follistatin:activin complex Identifiers Symbol Kazal_1 Pfam PF00050 InterPro IPR002350...
develop into pseudohypertrophy. Anabolism Colorado Experiment Davis' law Follistatin Lean body mass Muscle atrophy Muscle dystrophy Myostatin Pseudoathletic...
Global Information
