Erythromycin. The macrolide ring is the lactone (cyclic ester) at upper left.ClarithromycinRoxithromycin
Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but is now used as an immunosuppressant drug and is being investigated as a potential longevity therapeutic.[1]
Macrolides are bacteriostatic in that they suppress or inhibit bacterial growth rather than killing bacteria completely.
^Arriola Apelo SI, Lamming DW (July 2016). "apamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island". J Gerontol A Biol Sci Med Sci. 71 (7): 841–9. doi:10.1093/gerona/glw090. PMC 4906330. PMID 27208895. Retrieved 17 July 2022.
Macrolides are a class of mostly natural products with a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine...
confirmed, but it is likely safe. Azithromycin is an azalide, a type of macrolide antibiotic. It works by decreasing the production of protein, thereby...
also applies if taken directly by the baby during this age. It is in the macrolide family of antibiotics and works by decreasing bacterial protein production...
phenotype known as iMLSB. This phenotype of bacteria are resistant to the macrolide-lincosamide-streptogramin B group of antibiotics, however, the resistance...
One important application are the many macrocyclic antibiotics, the macrolides, e.g. clarithromycin. Many metallocofactors are bound to macrocyclic ligands...
been reported. It may cause harm if taken during pregnancy. It is in the macrolide class and works by slowing down bacterial protein synthesis. Clarithromycin...
either alone (mild to moderate severity disease) or in combination with a macrolide. The World Health Organization (WHO) recommends amoxicillin as first-line...
Rachel Fuller Brown and Elizabeth Lee Hazen. It was the first polyene macrolide antifungal. It is on the World Health Organization's List of Essential...
to macrolide treatment have been isolated and found to possess mutations at the transferase binding pocket in the 23S ribosomal subunit. Macrolide-resistant...
their tonsils. A drug-resistant strain of scarlet fever, resistant to macrolide antibiotics such as erythromycin, but retaining drug-sensitivity to beta-lactam...
but as an indicator it is not accurate enough to decide whether or not macrolide treatment should be used. The presence of chest pain in children with...
clarithromycin, or azithromycin are typically the recommended treatment. Newer macrolides are frequently recommended due to lower rates of side effects....
minimal relief provided for asthma symptoms. Macrolide antibiotics, particularly the azalide macrolide azithromycin, are a recently added GINA-recommended...
a class of macrolide antibiotics that were originally manufactured in response to the poor acid stability exhibited by original macrolides (erythromycin)...
such as certain anti-arrhythmics, anti-depressants, and quinolone or macrolide antibiotics. Another condition that promotes arrhythmias is Wolff-Parkinson-White...
biosynthesis of the antibiotic erythromycin by C6-hydroxylation of the macrolide 6-deoxyerythronolide B. Cytochrome P450 BM3 (CYP102A1) from the soil bacterium...
the genus Saccharopolyspora. Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin. Cytochrome P450 eryF (CYP107A1) originally from...
recommended. In those who are allergic to penicillin, cephalosporins or macrolides may be used. In children with frequent episodes of tonsillitis, tonsillectomy...
Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis...
bactericidal activities, killing the bacteria. Protein synthesis inhibitors (macrolides, lincosamides, and tetracyclines) are usually bacteriostatic, inhibiting...
Desosamine is a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics (contain a high level of microbial resistance) such as the...
ISBN 978-0-9626523-7-0. Rodvold KA, Piscitelli SC (August 1993). "New oral macrolide and fluoroquinolone antibiotics: an overview of pharmacokinetics, interactions...
Urinary antigen test, sputum culture Effective antibiotics include most macrolides, tetracyclines, ketolides, and quinolones. No Legionella pneumophila Pontiac...
especially to the commonly used tetracycline (e.g., doxycycline) and macrolide antibiotics (e.g., topical erythromycin). Therefore, dermatologists prefer...
cause is isolated or suspected. If antibiotics are to be employed, a macrolide (such as azithromycin) is preferred over a fluoroquinolone due to higher...
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