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Saccharopolyspora erythraea information


Saccharopolyspora erythraea
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Actinomycetota
Class: Actinomycetia
Order: Pseudonocardiales
Family: Pseudonocardiaceae
Genus: Saccharopolyspora
Species:
S. erythraea
Binomial name
Saccharopolyspora erythraea
(Waksman 1923) Labeda 1987
Synonyms[1]
  • "Actinomyces erythreus" Waksman 1923
  • Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 (Approved Lists 1980)

Saccharopolyspora erythraea is a species of actinomycete bacteria within the genus Saccharopolyspora.

Saccharopolyspora erythraea produces the macrolide antibiotic erythromycin.[2] Cytochrome P450 eryF (CYP107A1) originally from the bacterium is responsible for the biosynthesis of the antibiotic by C6-hydroxylation of the macrolide 6-deoxyerythronolide B.[3][4]

Small non-coding RNAs have been suggested to be involved in regulation of the secondary metabolite biosynthesis.[5]

  1. ^ Labeda, David P. (1987-01-01). "Transfer of the Type Strain of Streptomyces erythraeus (Waksman 1923) Waksman and Henrici 1948 to the Genus Saccharopolyspora Lacey and Goodfellow 1975 as Saccharopolyspora erythraea sp. nov., and Designation of a Neotype Strain for Streptomyces erythraeus". International Journal of Systematic Bacteriology. 37 (1): 19. doi:10.1099/00207713-37-1-19.
  2. ^ Oliynyk, Markiyan; Samborskyy, Markiyan; Lester, John B.; Mironenko, Tatiana; Scott, Nataliya; Dickens, Shilo; Haydock, Stephen F.; Leadlay, Peter F. (2007). "Complete genome sequence of the erythromycin-producing bacterium : Saccharopolyspora erythraea: NRRL23338". Nature Biotechnology. 25 (4): 447–453. doi:10.1038/nbt1297. PMID 17369815.
  3. ^ Cupp-Vickery, JR; Poulos, TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology. 2 (2): 144–53. doi:10.1038/nsb0295-144. PMID 7749919. S2CID 22536232.
  4. ^ Harris, DL (20 September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450 eryF". Journal of Inorganic Biochemistry. 91 (4): 568–85. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.
  5. ^ Liu, Wei-Bing; Shi, Yang; Yao, Li-Li; Zhou, Ying; Ye, Bang-Ce (2013-01-01). "Prediction and characterization of small non-coding RNAs related to secondary metabolites in Saccharopolyspora erythraea". PLOS ONE. 8 (11): e80676. Bibcode:2013PLoSO...880676L. doi:10.1371/journal.pone.0080676. ISSN 1932-6203. PMC 3827479. PMID 24236194.

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Saccharopolyspora erythraea

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Saccharopolyspora erythraea is a species of actinomycete bacteria within the genus Saccharopolyspora. Saccharopolyspora erythraea produces the macrolide...

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Erythromycin

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production. Erythromycin was first isolated in 1952 from the bacteria Saccharopolyspora erythraea. It is on the World Health Organization's List of Essential Medicines...

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Saccharopolyspora

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Saccharopolyspora is a genus of bacteria within the family Pseudonocardiaceae. Saccharopolyspora comprises the following species: S. antimicrobica Yuan...

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Production of antibiotics

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by what was called Streptomyces erythreus and is now known as Saccharopolyspora erythraea. Streptomycin is produced by Streptomyces griseus. Tetracycline...

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Secondary metabolite

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soil-dwelling myxobacterium Sorangium cellulosum. Erythromycin, Saccharopolyspora erythraea. Nystatin, from Streptomyces noursei. Rifamycin, from Amycolatopsis...

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Aminoglycoside

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antibiotic, and erythromycin, a macrolide antibiotic produced by Saccharopolyspora erythraea, along with its synthetic derivatives clarithromycin and azithromycin...

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Abelardo Aguilar

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backyard and had discovered a method to formulate erythromycin. Saccharopolyspora erythraea, a strain of bacteria was isolated and lead to his discovery...

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Streptomyces

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nomenclature are usually based on their color of hyphae and spores. Saccharopolyspora erythraea was formerly placed in this genus (as Streptomyces erythraeus)...

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CYP107 family

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identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea. Many enzymes of this family are involved in the synthesis of...

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Cytochrome P450 eryF

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is an Actinomycetota Cytochrome P450 enzyme originally from Saccharopolyspora erythraea, catalyzes the 6S-hydroxylate of 6-deoxyerythronolide B (6-DEB)...

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Erythronolide synthase

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part of a Type 1 polyketide synthase module. DEBS is found in Saccharopolyspora erythraea and other actinobacteria, and is responsible for the synthesis...

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RpoB

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produce naturally occurring antibiotics such as erythromycin (Saccharopolyspora erythraea) and vancomycin (Amycolatopsis orientalis) certain rpoB mutations...

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Streptomyces isolates

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coelicolor, Streptomyces avermitilis, Streptomyces griseus, and Saccharopolyspora erythraea, are capable of secondary metabolite production. Streptomyces...

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Benzoate degradation via hydroxylation

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103028 Pseudomonas putida 100650 Rhodococcus opacus 108011 Saccharomonospora cyanea 14841 Saccharopolyspora erythraea 13426 Streptomyces ghanaensis 15414...

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