MEIS1 information

MEIS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XRS
Identifiers
Aliases	MEIS1, Meis homeobox 1
External IDs	OMIM: 601739; MGI: 104717; HomoloGene: 135741; GeneCards: MEIS1; OMA:MEIS1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	66,573,869 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	18,968,985 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastric mucosa; ; body of uterus; ; canal of the cervix; ; left uterine tube; ; stromal cell of endometrium; ; ectocervix; ; palpebral conjunctiva; ; right adrenal gland; ; myometrium;
	Top expressed in
	vestibular membrane of cochlear duct; ; lacrimal gland; ; parotid gland; ; external carotid artery; ; efferent ductule; ; vas deferens; ; superior cervical ganglion; ; conjunctival fornix; ; urethra; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding;
Cellular component	transcription regulator complex; nucleus;
Biological process	megakaryocyte development; regulation of transcription, DNA-templated; blood vessel morphogenesis; negative regulation of neuron differentiation; locomotory behavior; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; lens morphogenesis in camera-type eye; angiogenesis; definitive hemopoiesis; negative regulation of myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; negative regulation of cardiac muscle cell proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	4211
	17268
	ENSG00000143995
	ENSMUSG00000020160
	O00470
	Q60954
	NM_002398
	NM_001193271; NM_010789
	NP_002389
	NP_001180200; NP_034919
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143995 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020160 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. doi:10.1128/mcb.15.10.5434. PMC 230793. PMID 7565694.
^ "Entrez Gene: MEIS1 Meis homeobox 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143995 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020160 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7565694-5] Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology. 15 (10): 5434–43. doi:10.1128/mcb.15.10.5434. PMC 230793. PMID 7565694.

[entrez-6] "Entrez Gene: MEIS1 Meis homeobox 1".

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List of human transcription factors

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PBX2

PBX1

ELF1

Cardiomyocyte proliferation

CCDC177

MEIS2

Myogenin

Metabolic regulation of hematopoiesis

HOXD11

PKNOX1

HOXD12

HOXA9

Homeobox A10

HOXB3

HOXA7

PBX3

TMEM211

HOXB6

HOXB13