HOXD12 information

HOXD12
Identifiers
Aliases	HOXD12, HOX4H, homeobox D12
External IDs	OMIM: 142988; MGI: 96204; HomoloGene: 7369; GeneCards: HOXD12; OMA:HOXD12 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	176,102,489 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	74,508,049 bp
RNA expression pattern
	Top expressed in
	vagina; ; muscle layer of sigmoid colon; ; rectum; ; ectocervix; ; prostate; ; canal of the cervix; ; urinary bladder; ; wall of uterus; ; myometrium; ; kidney;
	Top expressed in
	genital tubercle; ; urethra; ; tail of embryo; ; female urethra; ; male urethra; ; muscle layer of urethra; ; hand; ; epithelium of male urethra; ; footplate; ; sclerotome;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex;
Biological process	pattern specification process; multicellular organism development; skeletal system development; embryonic digit morphogenesis; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	3238
	15432
	ENSG00000170178
	ENSMUSG00000001823
	P35452
	P23812
	NM_021193
	NM_008274
	NP_067016
	NP_032300
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.^[5]^[6]^[7]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd12 gene plays a role in axial skeleton development and forelimb morphogenesis.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170178 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001823 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ D'Esposito M, Morelli F, Acampora D, Migliaccio E, Simeone A, Boncinelli E (July 1991). "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Genomics. 10 (1): 43–50. doi:10.1016/0888-7543(91)90482-T. PMID 1675198.
^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ "Entrez Gene: HOXD12 homeobox D12".
^ Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development. 122 (4): 1175–85. doi:10.1242/dev.122.4.1175. PMID 8620844.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170178 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001823 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1675198-5] D'Esposito M, Morelli F, Acampora D, Migliaccio E, Simeone A, Boncinelli E (July 1991). "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Genomics. 10 (1): 43–50. doi:10.1016/0888-7543(91)90482-T. PMID 1675198.

[pmid1973146-6] McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[entrez-7] "Entrez Gene: HOXD12 homeobox D12".

[pmid8620844-8] Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development. 122 (4): 1175–85. doi:10.1242/dev.122.4.1175. PMID 8620844.

HOXD12 information

and 6 Related for: HOXD12 information

HOXD12

Hox gene

List of human transcription factors

Homeobox

HOTAIR

Apical ectodermal ridge