MEIS2 information

MEIS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3K2A, 5BNG, 4XRM
Identifiers
Aliases	MEIS2, HsT18361, MRG1, Meis homeobox 2, CPCMR
External IDs	OMIM: 601740; MGI: 108564; HomoloGene: 7846; GeneCards: MEIS2; OMA:MEIS2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	37,101,299 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	115,896,320 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; pancreatic ductal cell; ; parotid gland; ; palpebral conjunctiva; ; mucosa of paranasal sinus; ; tail of epididymis; ; external globus pallidus; ; parietal pleura; ; body of uterus;
	Top expressed in
	Rostral migratory stream; ; vas deferens; ; dorsal striatum; ; genital tubercle; ; ventricular zone; ; ganglionic eminence; ; olfactory bulb; ; olfactory tubercle; ; medial ganglionic eminence; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; transcription coregulator activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus;
Biological process	eye development; visual learning; regulation of transcription, DNA-templated; response to mechanical stimulus; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; pancreas development; response to growth factor; negative regulation of myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of mitotic cell cycle; positive regulation of cardiac muscle myoblast proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4212
	17536
	ENSG00000134138
	ENSMUSG00000027210
	O14770
	P97367
NM_001220482; NM_002399; NM_020149; NM_170674; NM_170675;
	NM_170676; NM_170677; NM_172315; NM_172316
NM_001136072; NM_001159567; NM_001159568; NM_001159569; NM_001159570;
	NM_010825; NM_001346036; NM_001346038; NM_001346041; NM_001346044; NM_001346045; NM_001346047; NM_001346053; NM_001346055; NM_001346056
NP_001207411; NP_002390; NP_733774; NP_733775; NP_733776;
	NP_733777; NP_758526; NP_758527
NP_001129544; NP_001153039; NP_001153040; NP_001153041; NP_001153042;
	NP_001332965; NP_001332967; NP_001332970; NP_001332973; NP_001332974; NP_001332976; NP_001332982; NP_001332984; NP_001332985; NP_034955
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.^[5]^[6]

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134138 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027210 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K (Jan 1998). "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene". Mamm Genome. 8 (12): 951–2. doi:10.1007/s003359900621. PMID 9383298. S2CID 20187903.
^ ^a ^b "Entrez Gene: MEIS2 Meis homeobox 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134138 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027210 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9383298-5] Smith JE, Afonja O, Yee HT, Inghirami G, Takeshita K (Jan 1998). "Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene". Mamm Genome. 8 (12): 951–2. doi:10.1007/s003359900621. PMID 9383298. S2CID 20187903.

[entrez-6] "Entrez Gene: MEIS2 Meis homeobox 2".

MEIS2 information

and 7 Related for: MEIS2 information

MEIS2

List of human transcription factors

Limb development

KMT2A

Homeobox

Islands of Calleja

Homeobox protein TGIF1