RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular component
nucleus
transcription regulator complex
cytoplasm
Biological process
regulation of transcription, DNA-templated
endothelial cell activation
transcription, DNA-templated
multicellular organism development
regulation of transcription by RNA polymerase II
negative regulation of myeloid cell differentiation
spermatogenesis
single fertilization
male gonad development
anterior/posterior pattern specification
proximal/distal pattern formation
regulation of gene expression
mammary gland development
embryonic forelimb morphogenesis
positive regulation of transcription by RNA polymerase II
embryonic skeletal system development
uterus development
definitive hemopoiesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3205
15405
Ensembl
ENSG00000078399
ENSMUSG00000038227
UniProt
P31269
P09631
RefSeq (mRNA)
NM_152739 NM_002142
NM_001277238 NM_010456
RefSeq (protein)
NP_689952
NP_001264167 NP_034586
Location (UCSC)
Chr 7: 27.16 – 27.18 Mb
Chr 6: 52.2 – 52.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene.[5][6]
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila fly. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis.[7]
As HOXA9 dysfunction has been implicated in acute myeloid leukemia,[8] and expression of the gene has been shown to differ markedly between erythrocyte lineages of different stages of development,[9] the gene is of particular interest from a hematopoietic perspective.
^ abcGRCh38: Ensembl release 89: ENSG00000078399 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000038227 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, et al. (February 1996). "Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia". Nature Genetics. 12 (2): 154–158. doi:10.1038/ng0296-154. PMID 8563753. S2CID 6400265.
^Kingsley PD, Greenfest-Allen E, Frame JM, Bushnell TP, Malik J, McGrath KE, et al. (February 2013). "Ontogeny of erythroid gene expression". Blood. 121 (6): e5–e13. doi:10.1182/blood-2012-04-422394. PMC 3567347. PMID 23243273.
Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. In vertebrates, the genes encoding the class of transcription factors...
homeodomain-containing proteins. MEIS1 has been shown to interact with PBX1 and HOXA9. GRCh38: Ensembl release 89: ENSG00000143995 – Ensembl, May 2017 GRCm38:...
in higher vertebrates, or one of the following genes associated with it: HOXA9 HOXA11 HOXA11-AS1 (gene) HOXA13 HOXA, the Hazaribagh Old Xaverians Association...
ENSG00000122592 Homeodomain Known motif – High-throughput in vitro [381] TAATKRV HOXA9 ENSG00000078399 Homeodomain Known motif – High-throughput in vitro [382]...
histocompatibility complex (MHC) on chromosome 6. PBX2 has been shown to interact with HOXA9. ENSG00000237344, ENSG00000236353, ENSG00000232005, ENSG00000225987, ENSG00000206315...
(2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis". Gene Expr...
transcript 1 protein HOXA@: encoding protein Homeobox a cluster HOXA10-HOXA9: readthrough gene unlikely to produce a protein product HPC4: Prostate cancer...
PMC 358760. PMID 7910944. Shen WF, Rozenfeld S, Kwong A, et al. (1999). "HOXA9 Forms Triple Complexes with PBX2 and MEIS1 in Myeloid Cells". Mol. Cell...
degradation is HOXA9, which is essential for haematopoietic stem cell maintenance and has been implicated in a subset of myeloid leukemias. The HOXA9 degron lies...
of transcription factors that influence stem cell fate decisions (HOXB4, HOXA9, c-Myb, HIF1A) and has unraveled the pathobiology of several congenital...
identified as targets of EZH2-mediated transcriptional repression include HOXA9, HOXC8, MYT1, CDKN2A and retinoic acid target genes. In cancer, EZH2 may...
molecular mechanism(s) for this is unknown. Some HOXA genes, particularly HOXA9, are upregulated in these NUTM1 fusion gene-associated ALL cases as well...
at the gene for HOXA9 transcription factor and DNA hypermethylation is observed at the FOXP3 immune response gene promoter region. HOXA9 codes for a protein...
involving this gene often lead to leukemia. MLL's target genes include HOXC8, HOXA9, CDKN1B, and C-MYC. MLL also has two binding domains: a Cyp33 RNA-recognition...
Méchine-Neuville A, Lefebvre O, Bellocq JP, et al. (2003). "[Increased expression of HOXA9 gene in Hirschsprung disease]". Gastroenterol. Clin. Biol. 26 (12): 1110–7...
methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets". Molecular Cancer. 6: 45....
"Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation...
15 months. Research has found when BAALC is combined with the oncogene Hoxa9, BAALC blocks myeloid differentiation. This blocking induces leukemogenesis...
methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets". Molecular Cancer. 6: 45....
understood. It is thought that ID4 plays a role in the transcription of HOXA9 and CDKN1A which are known to be associated with endometriosis. A genome...
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