CHEK2 information

CHEK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GXC, 2CN5, 2CN8, 2W0J, 2W7X, 2WTC, 2WTD, 2XBJ, 2XM8, 2XM9, 2YCF, 2YCQ, 2YCR, 2YCS, 2YIQ, 2YIR, 2YIT, 3I6U, 3I6W, 4A9R, 4A9S, 4A9T, 4A9U, 4BDA, 4BDB, 4BDC, 4BDD, 4BDE, 4BDF, 4BDG, 4BDH, 4BDI, 4BDJ, 4BDK, 2WTI, 2WTJ, 2XK9
Identifiers
Aliases	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, checkpoint kinase 2
External IDs	OMIM: 604373; MGI: 1355321; HomoloGene: 38289; GeneCards: CHEK2; OMA:CHEK2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	28,742,422 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	111,022,011 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; mucosa of transverse colon; ; tibial nerve; ; oocyte; ; secondary oocyte; ; rectum; ; ventricular zone; ; left ovary; ; right ovary;
	Top expressed in
	morula; ; morula; ; fetal liver hematopoietic progenitor cell; ; epiblast; ; Ileal epithelium; ; blastocyst; ; embryo; ; Paneth cell; ; primitive streak; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; metal ion binding; protein serine/threonine kinase activity; protein binding; identical protein binding; protein kinase binding; ATP binding; ubiquitin protein ligase binding; kinase activity;
Cellular component	PML body; Golgi apparatus; nucleoplasm; telomere; nucleus; cytoplasm;
Biological process	positive regulation of protein phosphorylation; regulation of transcription, DNA-templated; cellular response to bisphenol A; negative regulation of DNA damage checkpoint; phosphorylation; signal transduction in response to DNA damage; replicative senescence; DNA damage checkpoint signaling; protein stabilization; transcription, DNA-templated; cellular response to DNA damage stimulus; cell division; positive regulation of transcription, DNA-templated; protein phosphorylation; mitotic spindle assembly; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to DNA damage; DNA damage induced protein phosphorylation; regulation of protein catabolic process; protein autophosphorylation; cell cycle; positive regulation of anoikis; response to gamma radiation; apoptotic process; double-strand break repair; DNA repair; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; regulation of apoptotic process; cellular response to gamma radiation; response to glycoside; mitotic DNA damage checkpoint signaling;
	Sources:Amigo / QuickGO
Orthologs
	11200
	50883
	ENSG00000183765
	ENSMUSG00000029521
	O96017
	Q9Z265
	NM_001005735; NM_001257387; NM_007194; NM_145862; NM_001349956
	NM_016681; NM_001363308
	NP_001005735; NP_001244316; NP_009125; NP_665861; NP_001336885
	NP_057890; NP_001350237
	Wikidata
View/Edit Human	View/Edit Mouse

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183765 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029521 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "CHEK2". Genetics Home Reference. August 2007. Archived from the original on 2015-04-25. Retrieved 2015-04-22.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183765 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029521 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Genetics_Home_Reference-5] "CHEK2". Genetics Home Reference. August 2007. Archived from the original on 2015-04-25. Retrieved 2015-04-22.

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