regulation of signal transduction by p53 class mediator
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
11073
235559
Ensembl
ENSG00000163781
ENSMUSG00000032555
UniProt
Q92547
Q6ZQF0
RefSeq (mRNA)
NM_007027 NM_001363889
NM_176979
RefSeq (protein)
NP_008958 NP_001350818 NP_008958.2
NP_795953
Location (UCSC)
Chr 3: 133.6 – 133.66 Mb
Chr 9: 103.18 – 103.23 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene.[5][6][7]
TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name.[8] TOPBP1 is involved in a variety of nuclear specific events. These include DNA damage repair, DNA replication, transcriptional regulation, and cell cycle checkpoint activation. TOPBP1 primarily regulates the DNA damage repair response through its ability to activate the damage response kinase, ataxia-telangiectasia mutated and RAD3-related (ATR). It also plays a critical role in DNA replication initiation and regulation of the cell cycle. Changes in TOPBP1 gene expression are associated with pulmonary hypertension, breast cancer, glioblastoma, non-small cell lung cancer, and sarcomas.[9][10][11]
^ abcGRCh38: Ensembl release 89: ENSG00000163781 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032555 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamane K, Kawabata M, Tsuruo T (December 1997). "A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator". European Journal of Biochemistry. 250 (3): 794–799. doi:10.1111/j.1432-1033.1997.00794.x. PMID 9461304.
^Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^"Entrez Gene: TOPBP1 topoisomerase (DNA) II binding protein 1".
^Broderick R, Niedzwiedz W (2015-08-12). "Sister chromatid decatenation: bridging the gaps in our knowledge". Cell Cycle. 14 (19): 3040–3044. doi:10.1080/15384101.2015.1078039. PMC 4825568. PMID 26266709.
^Ranchoux B, Meloche J, Paulin R, Boucherat O, Provencher S, Bonnet S (June 2016). "DNA Damage and Pulmonary Hypertension". International Journal of Molecular Sciences. 17 (6): 990. doi:10.3390/ijms17060990. PMC 4926518. PMID 27338373.
^Wardlaw CP, Carr AM, Oliver AW (October 2014). "TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways". DNA Repair. 22: 165–174. doi:10.1016/j.dnarep.2014.06.004. PMID 25087188.
^Toh M, Ngeow J (September 2021). "Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications". The Oncologist. 26 (9): e1526–e1537. doi:10.1002/onco.13829. PMC 8417864. PMID 34021944.
topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein...
this may lead to chromosome silencing. The DNA damage response protein TOPBP1 has also been identified as a crucial factor in meiotic sex chromosome silencing...
with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate...
brings in topoisomerase binding protein 1 (TOPBP1) which binds ATR through a highly conserved AAD. TOPBP1 binding is dependent on the phosphorylation...
and a group of proteins termed checkpoint mediators, such as TOPBP1 and Mrc1/claspin. TOPBP1 interacts with and recruits the phosphorylated Rad9 component...
factor and Small ubiquitin-related modifier 1, Sp1 transcription factor, TOPBP1, Thymine-DNA glycosylase, and Zinc finger and BTB domain-containing protein...
Bekker-Jensen S, Mailand N, et al. (2006). "Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation". Mol. Cell. Biol. 26 (16):...
M314017200. PMID 15136575. Yoshida K, Inoue I (2004). "Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription...
role in the formation of chromosomal crossovers. BRIP1 co-localizes with TOPBP1 scaffold protein and the BRCA1 repair protein along chromosome cores starting...
complex composed of CIP2A (the protein encoded by KIAA1524 gene), MDC1 and TOPBP1. CIP2A is over-expressed in several common human malignancies including...
Regulatory proteins such as replication protein A, Claspin, Tim/Tipin, Rad 17, TopBP1 may be involved to facilitate Chk1 activation. Additional protein interactions...
H, Uglehus RD, Johansen T (2007). "The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription"....
has been shown to interact with: CIB1, Karyopherin alpha 1, MAPK1, and TOPBP1. GRCh38: Ensembl release 89: ENSG00000104517 – Ensembl, May 2017 GRCm38:...
a process involving microtubule-dependent recruitment of the CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes. Inhibition or loss of MDC1 protein...
receptor, BCL2-like 1, Bcl-2, DNAJC7, HDAC1, HUS1 RAD1 homolog, RAD17, and TOPBP1. The Rad9 protein contains a carboxy-terminal tandem repeat of the BRCT...
humans is encoded by the ZBTB17 gene. ZBTB17 has been shown to interact with TOPBP1, Host cell factor C1 and Myc. GRCh38: Ensembl release 89: ENSG00000116809...
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