MBD4 information

MBD4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MOE, 3IHO, 4DK9, 4E9E, 4E9F, 4E9G, 4E9H, 4EA4, 4EA5, 4LG7, 4OFA, 4OFE, 4OFH, 5CHZ
Identifiers
Aliases	MBD4, MED1, methyl-CpG binding domain 4, DNA glycosylase
External IDs	OMIM: 603574; MGI: 1333850; HomoloGene: 2916; GeneCards: MBD4; OMA:MBD4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	129,440,179 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,830,332 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pylorus; ; visceral pleura; ; trabecular bone; ; caput epididymis; ; epithelium of nasopharynx; ; optic nerve; ; cardia; ; renal medulla; ; corpus epididymis;
	Top expressed in
	lumbar spinal ganglion; ; epithelium of male urethra; ; genital tubercle; ; tail of embryo; ; vagina; ; Rostral migratory stream; ; ejaculatory duct; ; pelvic part of vagina; ; epiblast; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; satellite DNA binding; endodeoxyribonuclease activity; protein binding; catalytic activity; hydrolase activity; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; DNA N-glycosylase activity;
Cellular component	chromatin; nucleus; nucleoplasm; nuclear speck;
Biological process	response to estradiol; depyrimidination; DNA repair; cellular response to DNA damage stimulus; response to radiation;
	Sources:Amigo / QuickGO
Orthologs
	8930
	17193
	ENSG00000129071
	ENSMUSG00000030322
	O95243
	Q9Z2D7
	NM_001276270; NM_001276271; NM_001276272; NM_001276273; NM_003925
	NM_010774
	NP_001263199; NP_001263200; NP_001263201; NP_001263202; NP_003916
	NP_034904
	Wikidata
View/Edit Human	View/Edit Mouse

Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129071 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030322 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hendrich B, Bird A (Nov 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. doi:10.1128/mcb.18.11.6538. PMC 109239. PMID 9774669.
^ Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung AT, Matsumoto Y, Golemis EA, Genuardi M, Neri G (May 1999). "MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1". Proc Natl Acad Sci U S A. 96 (7): 3969–74. Bibcode:1999PNAS...96.3969B. doi:10.1073/pnas.96.7.3969. PMC 22404. PMID 10097147.
^ "Entrez Gene: MBD4 methyl-CpG binding domain protein 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129071 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030322 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9774669-5] Hendrich B, Bird A (Nov 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. doi:10.1128/mcb.18.11.6538. PMC 109239. PMID 9774669.

[pmid10097147-6] Bellacosa A, Cicchillitti L, Schepis F, Riccio A, Yeung AT, Matsumoto Y, Golemis EA, Genuardi M, Neri G (May 1999). "MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1". Proc Natl Acad Sci U S A. 96 (7): 3969–74. Bibcode:1999PNAS...96.3969B. doi:10.1073/pnas.96.7.3969. PMC 22404. PMID 10097147.

[entrez-7] "Entrez Gene: MBD4 methyl-CpG binding domain protein 4".

MBD4 information

and 18 Related for: MBD4 information

MBD4

Base excision repair

DNA glycosylase

CpG site

List of human transcription factors

Reactive oxygen species

Reprogramming

Epigenetics in learning and memory

DNA demethylation

Sensenbrenner syndrome

DNA oxidation

MLH1

MBD3

SMUG1

FADD

Peter Keightley

MBD1

MIZF