The M1 protein is a matrix protein of the influenza virus. It forms a coat inside the viral envelope. This is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously.[1]
The M1 protein binds to the viral RNA. The binding is not specific to any RNA sequence, and is performed via a peptide sequence rich in basic amino acids.[citation needed]
It also has multiple regulatory functions, performed by interaction with the components of the host cell. The mechanisms regulated include a role in the export of the viral ribonucleoproteins from the host cell nucleus, inhibition of viral transcription, and a role in the virus assembly and budding. The protein was found to undergo phosphorylation in the host cell.[citation needed]
The M1 protein forms a layer under the patches of host cell membrane that are rich with the viral hemagglutinin, neuraminidase and M2 transmembrane proteins, and facilitates budding of the mature viruses.[citation needed]
M1 consists of two domains connected by a linker sequence. The N-terminal domain has a multi-helical structure that can be divided into two subdomains.[2] The C-terminal domain also contains alpha-helical structure.
^Sha B, Luo M (March 1997). "Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1". Nat. Struct. Biol. 4 (3): 239–44. doi:10.1038/nsb0397-239. PMID 9164466. S2CID 22521750.
^Arzt S, Baudin F, Barge A, Timmins P, Burmeister WP, Ruigrok RW (January 2001). "Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer". Virology. 279 (2): 439–46. doi:10.1006/viro.2000.0727. PMID 11162800.
M1protein is a matrix protein of the influenza virus. It forms a coat inside the viral envelope. This is a bifunctional membrane/RNA-binding protein...
supply M1 Finance, an online financial services company M1 Abrams, a main battle tank M1 armored car M1 Combat Car, an early tank M1 Light Tractor M1 Medium...
The matrix protein (M1) and membrane protein (M2) share a segment, as do the non-structural protein (NS1) and the nuclear export protein (NEP). For influenza...
herpesviruses, retroviruses, filoviruses and other groups. An example is the M1protein of the influenza virus, showing affinity to the glycoproteins inserted...
evolution of the matrix protein (M1) and nucleoprotein (NP), are used to determine if the virus is type A, B, C, or D. The M1protein is required for virus...
7 encodes two matrix proteins (M1 and M2) by using different reading frames from the same RNA segment. About 3,000 matrix protein molecules are needed...
by low pH. The M2 protein is encoded on the seventh RNA segment together with the M1protein. Proton conductance by the M2 protein in influenza A is essential...
antigens, matrix protein (M1) and nucleoprotein (NP), are used to determine if an influenza virus is type A, B, C, or D. The M1protein is required for...
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the...
been determined, named M1–M5 (using an upper case M and subscript number). M1, M3, M5 receptors are coupled with Gq proteins, while M2 and M4 receptors...
capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. It is the major structural protein within...
In molecular biology, VP40 is the name of a viral matrix protein. Most commonly, it is found in the Ebola virus (EBOV), a type of non-segmented, negative-strand...
effects on the protein to which they are attached, caused by differences in the conformations of the protein chains. K29-, K33-, K63- and M1-linked chains...
groups designated M1 and M2. M1 macrophages: as mentioned earlier (previously referred to as classically activated macrophages), M1 "killer" macrophages...
Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15...
In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the...
peptide antigens to highly conserved segments of the PA, PB1, PB2, NP & M1proteins, and has started phase I trials. DNA vaccines, such as VGX-3400X (aimed...
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilizes the fold...
Chroboczek J (December 2009). "Influenza recombinant vaccine: matrix proteinM1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385–93...
receptors. Epinephrine binds to the α1 GTPase Protein Coupled Receptor (GPCR) and acetylcholine binds to M1 and M2 GPCR. Binding of a primary messenger...
Heterotrimeric G protein, also sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated...
labeled M1 through M5. All of them function as G protein-coupled receptors, meaning that they exert their effects via a second messenger system. The M1, M3...
role in RNA alternative splicing and may influence the production of M1 and M2 proteins produced by splicing of this pre-mRNA. This structured region was...
Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense...