Global Information Lookup Global Information

M1 protein information


Flu_M1
influenza virus m1 protein
Identifiers
SymbolFlu_M1
PfamPF00598
InterProIPR001561
SCOP21aa7 / SCOPe / SUPFAM
OPM superfamily42
OPM protein1aa7
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The M1 protein is a matrix protein of the influenza virus. It forms a coat inside the viral envelope. This is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously.[1]

The M1 protein binds to the viral RNA. The binding is not specific to any RNA sequence, and is performed via a peptide sequence rich in basic amino acids.[citation needed]

It also has multiple regulatory functions, performed by interaction with the components of the host cell. The mechanisms regulated include a role in the export of the viral ribonucleoproteins from the host cell nucleus, inhibition of viral transcription, and a role in the virus assembly and budding. The protein was found to undergo phosphorylation in the host cell.[citation needed]

The M1 protein forms a layer under the patches of host cell membrane that are rich with the viral hemagglutinin, neuraminidase and M2 transmembrane proteins, and facilitates budding of the mature viruses.[citation needed]

M1 consists of two domains connected by a linker sequence. The N-terminal domain has a multi-helical structure that can be divided into two subdomains.[2] The C-terminal domain also contains alpha-helical structure.

  1. ^ Sha B, Luo M (March 1997). "Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1". Nat. Struct. Biol. 4 (3): 239–44. doi:10.1038/nsb0397-239. PMID 9164466. S2CID 22521750.
  2. ^ Arzt S, Baudin F, Barge A, Timmins P, Burmeister WP, Ruigrok RW (January 2001). "Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer". Virology. 279 (2): 439–46. doi:10.1006/viro.2000.0727. PMID 11162800.

and 26 Related for: M1 protein information

Request time (Page generated in 0.8009 seconds.)

M1 protein

Last Update:

M1 protein is a matrix protein of the influenza virus. It forms a coat inside the viral envelope. This is a bifunctional membrane/RNA-binding protein...

Word Count : 304

M1

Last Update:

supply M1 Finance, an online financial services company M1 Abrams, a main battle tank M1 armored car M1 Combat Car, an early tank M1 Light Tractor M1 Medium...

Word Count : 1028

Influenza

Last Update:

The matrix protein (M1) and membrane protein (M2) share a segment, as do the non-structural protein (NS1) and the nuclear export protein (NEP). For influenza...

Word Count : 12961

Viral matrix protein

Last Update:

herpesviruses, retroviruses, filoviruses and other groups. An example is the M1 protein of the influenza virus, showing affinity to the glycoproteins inserted...

Word Count : 247

Influenza C virus

Last Update:

evolution of the matrix protein (M1) and nucleoprotein (NP), are used to determine if the virus is type A, B, C, or D. The M1 protein is required for virus...

Word Count : 1899

Influenza A virus

Last Update:

7 encodes two matrix proteins (M1 and M2) by using different reading frames from the same RNA segment. About 3,000 matrix protein molecules are needed...

Word Count : 6760

M2 proton channel

Last Update:

by low pH. The M2 protein is encoded on the seventh RNA segment together with the M1 protein. Proton conductance by the M2 protein in influenza A is essential...

Word Count : 2294

Influenza D virus

Last Update:

antigens, matrix protein (M1) and nucleoprotein (NP), are used to determine if an influenza virus is type A, B, C, or D. The M1 protein is required for...

Word Count : 1848

Muscarinic acetylcholine receptor M1

Last Update:

The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the...

Word Count : 2214

Muscarinic acetylcholine receptor

Last Update:

been determined, named M1–M5 (using an upper case M and subscript number). M1, M3, M5 receptors are coupled with Gq proteins, while M2 and M4 receptors...

Word Count : 2707

P24 capsid protein

Last Update:

capsid protein is the most abundant HIV protein with each virus containing approximately 1,500 to 3,000 p24 molecules. It is the major structural protein within...

Word Count : 1461

Integral membrane protein

Last Update:

of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor"...

Word Count : 1035

VP40

Last Update:

In molecular biology, VP40 is the name of a viral matrix protein. Most commonly, it is found in the Ebola virus (EBOV), a type of non-segmented, negative-strand...

Word Count : 732

Ubiquitin

Last Update:

effects on the protein to which they are attached, caused by differences in the conformations of the protein chains. K29-, K33-, K63- and M1-linked chains...

Word Count : 11068

Macrophage

Last Update:

groups designated M1 and M2. M1 macrophages: as mentioned earlier (previously referred to as classically activated macrophages), M1 "killer" macrophages...

Word Count : 10143

Index of biophysics articles

Last Update:

activity Locomotor effects of shoes Luca Turin Lymphocyte homing receptor M1 protein M2 proton channel MHC class I Magnesium transporter Magnetoception Magnetosome...

Word Count : 1545

Gq alpha subunit

Last Update:

Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15...

Word Count : 1084

Protein kinase C

Last Update:

In cell biology, Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the...

Word Count : 2650

Universal flu vaccine

Last Update:

peptide antigens to highly conserved segments of the PA, PB1, PB2, NP & M1 proteins, and has started phase I trials. DNA vaccines, such as VGX-3400X (aimed...

Word Count : 2791

Zinc finger

Last Update:

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) which stabilizes the fold...

Word Count : 4825

Adenoviridae

Last Update:

Chroboczek J (December 2009). "Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron". Vaccine. 27 (52): 7385–93...

Word Count : 5557

Second messenger system

Last Update:

receptors. Epinephrine binds to the α1 GTPase Protein Coupled Receptor (GPCR) and acetylcholine binds to M1 and M2 GPCR. Binding of a primary messenger...

Word Count : 1338

Heterotrimeric G protein

Last Update:

Heterotrimeric G protein, also sometimes referred to as the "large" G proteins (as opposed to the subclass of smaller, monomeric small GTPases) are membrane-associated...

Word Count : 1237

Acetylcholine

Last Update:

labeled M1 through M5. All of them function as G protein-coupled receptors, meaning that they exert their effects via a second messenger system. The M1, M3...

Word Count : 4232

Influenza A segment 7 splice site

Last Update:

role in RNA alternative splicing and may influence the production of M1 and M2 proteins produced by splicing of this pre-mRNA. This structured region was...

Word Count : 750

Cas9

Last Update:

Cas9 (CRISPR associated protein 9, formerly called Cas5, Csn1, or Csx12) is a 160 kilodalton protein which plays a vital role in the immunological defense...

Word Count : 5610

PDF Search Engine © AllGlobal.net