neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
Cellular component
axon terminus
integral component of membrane
postsynaptic membrane
membrane
postsynaptic density
plasma membrane
integral component of plasma membrane
cell junction
dendrite
asymmetric synapse
synapse
Schaffer collateral - CA1 synapse
glutamatergic synapse
cholinergic synapse
integral component of postsynaptic membrane
integral component of presynaptic membrane
integral component of postsynaptic density membrane
Biological process
positive regulation of intracellular protein transport
G protein-coupled receptor signaling pathway
cognition
regulation of locomotion
synaptic transmission, cholinergic
saliva secretion
nervous system development
neuromuscular synaptic transmission
protein kinase C-activating G protein-coupled receptor signaling pathway
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
positive regulation of ion transport
positive regulation of cell population proliferation
phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
cell population proliferation
regulation of vascular associated smooth muscle contraction
signal transduction
G protein-coupled acetylcholine receptor signaling pathway
regulation of postsynaptic membrane potential
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
chemical synaptic transmission
G protein-coupled serotonin receptor signaling pathway
regulation of glial cell proliferation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1128
12669
Ensembl
ENSG00000168539
ENSMUSG00000032773
UniProt
P11229
P12657
RefSeq (mRNA)
NM_000738
NM_001112697 NM_007698
RefSeq (protein)
NP_000729
NP_001106167 NP_031724
Location (UCSC)
Chr 11: 62.91 – 62.92 Mb
Chr 19: 8.64 – 8.66 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that in humans is encoded by the CHRM1 gene.[5] It is localized to 11q13.[5]
This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve,[6] is common in exocrine glands and in the CNS.[7][8]
It is predominantly found bound to G proteins of class Gq[9][10] that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively.
^ abcGRCh38: Ensembl release 89: ENSG00000168539 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032773 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Messer WS (20 January 2000). "Acetylcholine". University of Toledo. Archived from the original on 14 October 2007. Retrieved 27 October 2007.
^Johnson G (2002). PDQ Pharmacology (2nd ed.). Hamilton, Ontario: BC Decker Inc. pp. 311 pages. ISBN 1-55009-109-3.
^Richelson E (1995). "Cholinergic Transduction". In Bloom FE, Kupfer DJ (eds.). Psychopharmacology: the fourth generation of progress: an official publication of the American College of Neuropsychopharmacology (Fourth ed.). New York: Lippincott Williams & Wilkins. ISBN 978-0781701662. Retrieved 27 October 2007.
^Qin K, Dong C, Wu G, Lambert NA (August 2011). "Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers". Nature Chemical Biology. 7 (10): 740–747. doi:10.1038/nchembio.642. PMC 3177959. PMID 21873996.
^Burford NT, Nahorski SR (May 1996). "Muscarinic m1 receptor-stimulated adenylate cyclase activity in Chinese hamster ovary cells is mediated by Gs alpha and is not a consequence of phosphoinositidase C activation". The Biochemical Journal. 315 (Pt 3): 883–888. doi:10.1042/bj3150883. PMC 1217289. PMID 8645172.
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