3D model of the flu virion. (M2 labeled in white.)
The Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer (consists of four identical M2 units), where the units are helices stabilized by two disulfide bonds, and is activated by low pH. The M2 protein is encoded on the seventh RNA segment together with the M1 protein. Proton conductance by the M2 protein in influenza A is essential for viral replication.
Influenza B and C viruses encode proteins with similar function dubbed "BM2" and "CM2" respectively. They share little similarity with M2 at the sequence level, despite a similar overall structure and mechanism.[1]
The Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer...
antiviral mechanism of action is antagonism of the influenzavirus A M2protonchannel, which prevents endosomal escape (i.e., the release of viral genetic...
effects of shoes Luca Turin Lymphocyte homing receptor M1 protein M2protonchannel MHC class I Magnesium transporter Magnetoception Magnetosome Magnetospirillum...
activity by binding to amino acids in the M2 transmembrane channel and blocking proton transport across the M2channel. Rimantadine is believed to inhibit influenza's...
other transporters and ion channels play a role in generating a proton electrochemical gradient. One is TPK3, a potassium channel that is activated by Ca2+...
the head of those proteins were identified. The highly conserved M2protonchannel was proposed as a potential target for broadly neutralizing antibodies...
selectivity; examples include the influenza A virus M2protonchannel protein, which is highly selective for protons and is active at low pH, and the Chlorella...
discovered. This protein family includes light-driven proton pumps, ion pumps and ion channels, as well as light sensors. For example, the proteins from...
acts as a proton pump; that is, it captures light energy and uses it to move protons across the membrane out of the cell. The resulting proton gradient...
the smaller M2protonchannel protein, which is produced by RNA splicing. M2 protein is critical to the virus: it forms the ion channels that allow for...
the particle accelerator Gustaf Werner cyclotron. The main activity is proton therapy for the treatment of cancer, based on an agreement between the Oncology...
rises from the protonation of transmembrane helices at the end of the pore. At low pH, the M2 helix is protonated, shifting the ion channel from closed to...
aneutronic reactions release energy in the form of charged particles, typically protons or alpha particles. Successful aneutronic fusion would greatly reduce problems...
the same chemical element. They have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to...
which incorporates the namesake Steam storefront. SteamOS uses Valve's Proton compatibility layer, allowing users to run Windows applications and games...
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...
However, in October 2008, Proton renewed its technology-transfer agreements with MMC, and the Proton Inspira (the Proton Waja replacement) was again...
muscarinic M2 receptors, this promotes dissociation of βγ subunit complexes, leading to direct opening of the G-protein–gated inwardly rectifying K+ channel (Girk/Kir)...
Dimensions: 5.8 x 2.4 x 2.4 m and a 27 m2 solar array DC power: 120 W Expected lifetime: 12 years Transponders: 32 Vehicle: Proton-K / Blok DM-03 Nimiq 2, launched...
pharmaceutical companies. A key target for potential therapy is the proton-gated urea channel, since the secretion of urease enables the survival of the bacterium...
is used on earth. They are radiation (high-speed atomic particles like proton and neutron, solar flare magnetic energy dissipation in Earth's space, energetic...
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