Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Lipoamide is a trivial name for 6,8-dithiooctanoic amide. It is the functional form of lipoic acid, i.e the carboxyl group is attached to protein via an amine with an amide linkage.[1] Illustrative of the biochemical role of lipoamide is in the conversion of pyruvate to acetyl lipoamide.[2]
Lipoamide is found in a large number of plant and animal-based foods.[1]
^ ab"Metabocard for Lipoamide". Human Metabolome Database. 14 September 2021. HMDB0000962. Retrieved 30 November 2022.
^J. M. Berg; J. L. Tymoczko, L. Stryer (2007). Biochemistry (6th ed.). Freeman. ISBN 978-0-7167-8724-2.
Illustrative of the biochemical role of lipoamide is in the conversion of pyruvate to acetyl lipoamide. Lipoamide is found in a large number of plant and...
dehydrogenase is an enzyme that catalyzes the reaction of pyruvate and a lipoamide to give the acetylated dihydrolipoamide and carbon dioxide. The conversion...
gene. DLD is a flavoprotein enzyme that oxidizes dihydrolipoamide to lipoamide. Dihydrolipoamide dehydrogenase (DLD) is a mitochondrial enzyme that plays...
unable to cleave the lipoic acid-L-lysine amide bond. Both synthetic lipoamide and (R)-lipoyl-L-lysine are rapidly cleaved by serum lipoamidases, which...
and subsequently enters the citric acid cycle. E2 can also be known as lipoamide reductase-transacetylase. The dihydrolipoate, covalently bound to a lysine...
A (CoA), and dihydrolipoyl dehydrogenase (EC 1.8.1.4) regenerates the lipoamide. Because dihydrolipoyl transacetylase is the second of the three enzyme...
molecule oxidized by dihydrolipoyl dehydrogenase in order to produce lipoamide. Lipoamide is subsequently used as a cofactor for α-ketoglutarate dehydrogenase...
been isolated from soil from Korea. Streptomyces seoulensis produces lipoamide dehydrogenase. Kim, In-Kwon; Yim, Yang-In; Kim, Young-Min; Lee, Jin-Won;...
an amide bond, to a lysine residue in enzymes requiring this coenzyme. Lipoamide acyltransferases have an essential cofactor, lipoic acid, which is covalently...
Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene. It codes for an isozyme of pyruvate...
C8H15NOS2 (molar mass: 205.341 g/mol, exact mass: 205.0595 u) may refer to: Lipoamide 6-(Methylsulfinyl)hexyl isothiocyanate This set index page lists chemical...
glutathione reductase, trypanothione reductase, mercuric reductase and lipoamide dehydrogenase. A low molecular weight (MW = ~ 35,000) type has been identified...
participate in a variety of biochemical transformations. Dihydrolipoamide Lipoamide Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred...
tetrahydrofolate-requiring aminomethyltransferase enzyme), and L protein (a lipoamide dehydrogenase). The H protein shuttles the methylamine group of glycine...
Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. It codes for an isozyme...
complex) in the pyruvate-acetyl CoA reaction, by binding to the –SH group of lipoamide, a participant coenzyme. It also inhibits the oxoglutarate dehydrogenase...
Pyruvate dehydrogenase lipoamide kinase isozyme 3, mitochondrial is an enzyme that in humans is encoded by the PDK3 gene. It codes for an isozyme of pyruvate...
dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded...
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