Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer.[1]
It was patented in 1986 and approved for medical use in 1996.[4] In 2021, it was the 222nd most commonly prescribed medication in the United States, with more than 1million prescriptions.[5][6] It is on the World Health Organization's List of Essential Medicines.[7]
^ ab"Femara- letrozole tablet, film coated". DailyMed. 13 May 2022. Retrieved 28 August 2022.
^"List of nationally authorised medicinal products : Active substance(s): letrozole : Procedure No. PSUSA/00001842/202110" (PDF). Ema.europa.eu. Retrieved 30 June 2022.
^ abc"Letrozole". 24 January 2003. Archived from the original on 24 January 2003. Retrieved 30 June 2022.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 516. ISBN 9783527607495.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Letrozole - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
Letrozole, sold under the brand name Femara among others, is an aromatase inhibitor medication that is used in the treatment of breast cancer. It was...
[citation needed] A study of 150 babies following treatment with letrozole or letrozole and follicle-stimulating hormone presented at the American Society...
survival in patients on palbociclib in combination with letrozole, compared to patients on letrozole and placebo. Progression-free survival was assessed by...
children and adolescents. Ovarian stimulation with the aromatase inhibitor letrozole has been proposed for ovulation induction in order to treat unexplained...
anastrozole and letrozole. They are used as first-line therapy in metastatic breast cancer and also in adjuvant treatment. The NSAI, letrozole is also used...
penetration of anastrozole in rodents, whereas this was not the case with letrozole and vorozole. As such, anastrozole may have peripheral selectivity in...
anovulation, but it appears less effective than letrozole or clomiphene. For women not responsive to letrozole or clomiphene and diet and lifestyle modification...
rates for women with PCOS treated with clomiphene compared to letrozole found that letrozole resulted in higher live birth rates. However, ovulation induction...
testing positive for the prohibited substance Letrozole. Errani claimed that she likely ingested letrozole by "accidentally consuming her mother's anti-cancer...
addition of PD-0332991 to letrozole trebled median time to disease progression to 26.1 months compared with 7.5 months for letrozole alone. The FDA granted...
than the mifepristone-misoprostol combination. Tests have shown that letrozole or methotrexate may be included in the mifepristone-misoprostol regimen...
androgen into estrogen. Type II aromatase inhibitors such as anastrozole and letrozole, by contrast, are not steroids and work by interfering with the aromatase's...
for two banned substances, clomiphene, an anti-estrogen substance, and letrozole, an aromatase inhibitor, prior to his scheduled championship bout with...
participants receiving placebo plus letrozole, progression-free survival was 16 months on average, while under ribociclib plus letrozole, progression-free survival...
1016/S1470-2045(23)00228-0. PMID 37269836. "Dalpiciclib in Combination with Letrozole or Anastrozole Significantly Improved Progression-free Survival in Systemic...
(goserelin, leuprolide, or triptorelin) and aromatase inhibitors (anastrozole, letrozole, or exemestane) slightly improves survival, but has more severe side effects...
loss in postmenopausal women with early breast cancer receiving adjuvant letrozole". The Oncologist. 13 (5): 503–514. doi:10.1634/theoncologist.2007-0206...
individuals have been treated with adjuvant hormonal therapy drugs, such as letrozole or anastrozole (which block the metabolism of androgen to estrogens by...
Estrogen alone does not have an effect on the cancer, and tamoxifen and letrozole are rarely effective. "Some women with borderline malignancy ovarian cancer...
endometriosis. Examples of aromatase inhibitors include anastrozole and letrozole. Evidence for aromatase inhibitors is confirmed by numerous controlled...
that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also beginning to be prescribed to men on testosterone...
with hormonal agents, including tamoxifen, hydroxyprogesterone caproate, letrozole, megestrol acetate, and medroxyprogesterone. This treatment is effective...
Global Information
