This article is about the medical therapy. For the cell cycle protein, see Cyclin-dependent kinase inhibitor protein.
A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by preventing overproliferation of cancer cells. The US FDA approved the first drug of this type, palbociclib (Ibrance),[1] a CDK4/6 inhibitor, in February 2015, for use in postmenopausal women with breast cancer that is estrogen receptor positive and HER2 negative. While there are multiple cyclin/CDK complexes regulating the cell cycle, CDK inhibitors targeting CDK4/6 have been the most successful; four CDK4/6 inhibitors have been FDA approved.[2] No inhibitors targeting other CDKs have been FDA approved, but several compounds are in clinical trials.
^"FDA approves Ibrance for postmenopausal women with advanced breast cancer". Food and Drug Administration. Archived from the original on 2018-01-26. Retrieved 2019-12-16.
^Mughal, Muhammad Jameel; Bhadresha, Kinjal; Kwok, Hang Fai (2023-01-01). "CDK inhibitors from past to present: A new wave of cancer therapy". Seminars in Cancer Biology. 88: 106–122. doi:10.1016/j.semcancer.2022.12.006. ISSN 1044-579X. PMID 36565895.
A CDK (cyclin-dependent kinase) inhibitor is any chemical that inhibits the function of CDKs. They are used to treat cancers by preventing overproliferation...
association (see above) with cyclin D1 CDKinhibitors are being studied in a variety of cancers. Palbociclib is a CDKinhibitor (approved for some breast cancer...
metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDKinhibitor selective for CDK4 and CDK6. It was designated as a breakthrough therapy...
families of genes, the cip/kip (CDK interacting protein/Kinase inhibitory protein) family and the INK4a/ARF (Inhibitor of Kinase 4/Alternative Reading...
of CDK, leading to the inactivation of certain tumor suppressor genes. When used in combination with other drugs such as an ALK or an MEK inhibitor, ribociclib...
protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of...
checkpoints can halt progression through the cell cycle by inhibiting certain cyclin-CDK complexes. Meiosis undergoes two divisions resulting in four...
the nucleus to the cytoplasm and avoids further transcription of the cdkinhibitor. Cdc28-Clb also phosphorylates any Sic1 molecules still available and...
cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes...
A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout...
also associate with Miz1 to activate expression of the Cdkinhibitor p15INK4b to block cyclin D-Cdk complex formation and activity. Cells arrested with...
CDK6. The other family of CKIs, CIP/KIP proteins are capable of inhibiting all CDKs. Enforced expression of INK4 proteins can lead to G1 arrest by promoting...
complex also targets p27Kip, a Cdkinhibitor of cyclin E and A. In addition, viral cyclin D-Cdk6 is resistant to Cdkinhibitors, such as p21CIP1/WAF1 and p16INK4a...
mTOR was made in 1994 while investigating the mechanism of action of its inhibitor, rapamycin. Rapamycin was first discovered in 1975 in a soil sample from...
non-peptidic proteasome inhibitor discovered was the natural product lactacystin. Disulfiram has been proposed as another proteasome inhibitor. Epigallocatechin-3-gallate...
have progressed after previous endocrine therapy. Dalpicicilib is a CDKinhibitor that targets the CDK4 and CDK6 isoforms. Chen X, Shen K (June 2023)...
Etoposide, and Atezolizumab With or Without Trilaciclib (G1T28), a CDK 4/6 Inhibitor, in Extensive Stage Small Cell Lung Cancer (SCLC)" at ClinicalTrials...
S and M cyclins (but not G1/S cyclins); and a high concentration of Cdkinhibitors is found during G1 phase. The restriction point (R) in the G1 phase...
and if positive for the BRAF V600 mutation, a BRAF inhibitor or BRAF inhibitor with an MEK inhibitor. Effectiveness was established based on objective...
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that...
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