Zoledronic acid, also known as zoledronate and sold under the brand name Zometa[4] by Novartis among others, is a medication used to treat a number of bone diseases.[3] These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone[3] and Duchenne muscular dystrophy (DMD). It is given by injection into a vein.[3]
Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired.[3] Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw.[3] Use during pregnancy may result in harm to the baby.[3] It is in the bisphosphonate family of medications.[3] It works by blocking the activity of osteoclast cells and thus decreases the breakdown of bone.[3]
Zoledronic acid was patented in 1986 and approved for medical use in the United States in 2001.[3][5] It is on the World Health Organization's List of Essential Medicines.[6][7]
^"International trade names for zoledronic acid". Drugs.com. Retrieved 14 January 2015.
^ ab"Zoledronic acid Use During Pregnancy". Drugs.com. 1 June 2020. Retrieved 19 October 2020.
^ abcdefghij"Zoledronic Acid". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
^"PRESS RELEASE: Novartis's Reclast Receives FDA Approval FOR Women With Postmenopausal Osteoporosis". FierceBiotech. 20 August 2007. Retrieved 2021-09-02.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 524. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
Zoledronicacid, also known as zoledronate and sold under the brand name Zometa by Novartis among others, is a medication used to treat a number of bone...
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