Synthesis of toxic substances from a non-toxic precursor
Lethal synthesis, or suicide metabolism,[1] is the biosynthesis of a toxin from a precursor which is not itself toxic, such as the synthesis of fluorocitrate from fluoroacetate or the synthesis of methylglyoxal from glycerol.[2][3][4]
The term was first publicised by Rudolph Peters in his Croonian Lecture of 1951.[5][3][6]
^"Lethal synthesis". Compendium of Chemical Terminology (the "Gold Book"). IUPAC. 2014. doi:10.1351/goldbook.L03501. Retrieved 2018-03-13.
^"Lethal synthesis". Oxford Reference. Oxford University Press. Retrieved 2018-03-12.
^ abvan der Kamp, Marc W.; McGeagh, John D.; Mulholland, Adrian J. (24 October 2011). ""Lethal Synthesis" of Fluorocitrate by Citrate Synthase Explained through QM/MM Modeling". Angewandte Chemie International Edition. 50 (44): 10349–10351. doi:10.1002/anie.201103260. PMID 21922613.
^Cite error: The named reference :0 was invoked but never defined (see the help page).
^Peters, R. A. (28 February 1952). "Croonian Lecture: Lethal Synthesis". Proceedings of the Royal Society B: Biological Sciences. 139 (895): 143–170. Bibcode:1952RSPSB.139..143P. doi:10.1098/rspb.1952.0001. PMID 14911820. S2CID 84782137.
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