Leptophos information

Leptophos
Names
	Preferred IUPAC name O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate
Identifiers
CAS Number	21609-90-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:82137;
ChemSpider	28496 ;
ECHA InfoCard	100.040.415
EC Number	244-472-8;
KEGG	C19003;
PubChem CID	30709;
UNII	C45E8FUG3Z;
UN number	3464 3018
CompTox Dashboard (EPA)	DTXSID3040279 ;
	InChI InChI=1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3 Key: CVRALZAYCYJELZ-UHFFFAOYSA-N ;
	SMILES c1([P@@](Oc2c(cc(Br)c(c2)Cl)Cl)(OC)=S)ccccc1;
Properties
Chemical formula	C13H10BrCl2O2PS
Molar mass	412.06 g·mol−1
Appearance	White crystalline solid
Density	1.53 g/cm3
Melting point	70 °C (158 °F; 343 K)
Boiling point	180 °C (356 °F; 453 K) (decomposes)
Solubility in water	0.0047 mg/l
log P	6.31
Vapor pressure	2.3E-8 mm Hg
Hazards
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H301, H312, H370, H410
Precautionary statements	P260, P264, P270, P273, P280, P301+P310, P302+P352, P307+P311, P312, P321, P322, P330, P363, P405, P501
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	Rat 135mg/kg (intraperitoneal) Rat 19mg/kg (oral) Rat 44mg/kg (skin)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Leptophos (O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate) belongs to the organophosphates and at room temperature it is a stable white solid. It is also known as Phosvel, Abar and Vcs 506. Leptophos was primarily used as a pesticide and fungicide.^[3] for rice, cotton, fruit and vegetables until its use was discontinued in 1975 in USA,^[4] but still sold in South-Eastern Asia in 1981.^[5]

Leptophos was first discovered to be toxic in 1974 when more than 1000 water buffaloes died after exposure to leptophos in Egypt. In response to this event, the effect of leptophos was investigated on chickens, mice and sheep.^[6]

^ Hansch, C; et al. (1995). {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
^ Gaja Peters; Inga Thede; Volkmar Vill; Ron Zenczykowski. "Landolt Börnstein/Property Index". Universatie of Hamburg. Retrieved 2012-03-02.
^ "338. Leptophos (WHO Pesticide Residues Serie 5)". Retrieved 8 March 2012.
^ Toxipedia. "Toxipedia: Leptophos".
^ Hulebak, Karen L. (1987). "Neurotoxicants: Emerging issues and policy options". Neurotoxicology and Teratology. 9 (2): 187–192. doi:10.1016/0892-0362(87)90097-3. PMID 3657755.
^ Shukla, O P; AK Kulshreth (1998). Pesticides, Man and Bioshere.

[1] Hansch, C; et al. (1995). {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)

[2] Gaja Peters; Inga Thede; Volkmar Vill; Ron Zenczykowski. "Landolt Börnstein/Property Index". Universatie of Hamburg. Retrieved 2012-03-02.

[3] "338. Leptophos (WHO Pesticide Residues Serie 5)". Retrieved 8 March 2012.

[4] Toxipedia. "Toxipedia: Leptophos".

[:0-5] Hulebak, Karen L. (1987). "Neurotoxicants: Emerging issues and policy options". Neurotoxicology and Teratology. 9 (2): 187–192. doi:10.1016/0892-0362(87)90097-3. PMID 3657755.

[6] Shukla, O P; AK Kulshreth (1998). Pesticides, Man and Bioshere.

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