dentate gyrus of hippocampal formation granule cell
prefrontal cortex
nucleus accumbens
primary motor cortex
cerebellar cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
G protein-coupled receptor activity
signal transducer activity
protein binding
transmembrane signaling receptor activity
cell adhesion molecule binding
carbohydrate binding
latrotoxin receptor activity
Cellular component
integral component of membrane
cell projection
membrane
growth cone
plasma membrane
synapse
cell junction
axon
neuron projection
presynaptic membrane
intracellular anatomical structure
integral component of plasma membrane
postsynaptic density
Biological process
G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
calcium-mediated signaling using intracellular calcium source
signal transduction
positive regulation of synapse assembly
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
positive regulation of synapse maturation
adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
22859
330814
Ensembl
ENSG00000072071 ENSG00000288324
ENSMUSG00000013033
UniProt
O94910
Q80TR1
RefSeq (mRNA)
NM_001008701 NM_014921
NM_181039
RefSeq (protein)
NP_001008701 NP_055736
NP_851382
Location (UCSC)
Chr 19: 14.15 – 14.21 Mb
Chr 8: 83.9 – 83.94 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene.[5][6] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[7][8][9]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000013033 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–131. doi:10.3109/10799890009150640. PMID 10994649. S2CID 19919738.
^"Entrez Gene: LPHN1 latrophilin 1".
^Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
Latrophilin1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized...
Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene. This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors...
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene. This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors...
Cannabinoid receptor 1 (CB1), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. The human CB1 receptor is expressed...
single nucleotide polymorphisms (SNPs) occurring in GABA receptor genes rho 1, 2, and 3 (GABBR1, GABBR2, and GABBR3) have been more recently explored in...
Angiotensin II receptor type 1 (AT1) is a Gq/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded...
"Neuromodulation of Neuronal Circuits: Back to the Future". Neuron. 76 (1): 1–11. doi:10.1016/j.neuron.2012.09.010. ISSN 0896-6273. PMC 3482119. PMID 23040802...
structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor". Journal of Medicinal Chemistry. 54 (23): 8195–8206. doi:10.1021/jm2011589...
results in the phosphorylation of DARPP-32, an inhibitor of protein phosphatase 1. Sustained D1 receptor activity is kept in check by Cyclin-dependent kinase...
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin...
82 °C for D2O), pKa (i.e., dissociation constant: 9.71x10−15 for H2O vs. 1.95x10−15 for D2O, cf. heavy water) and the strength of hydrogen bonding. Such...
M1 and M2 subtypes,[citation needed] while later studies recognize M3, M4,[1] and most recently M5 subtypes.[citation needed] Meanwhile, geneticists and...
mice, regulation of D2R surface expression by the neuronal calcium sensor-1 (NCS-1) in the dentate gyrus is involved in exploration, synaptic plasticity and...
2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent...
Global Information
