Laropiprant information

Laropiprant
Clinical data
Other names	MK-0524A
AHFS/Drugs.com	International Drug Names
ATC code	none;
Legal status
Legal status	Withdrawn;
Identifiers
	IUPAC name (−)-[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid;
CAS Number	571170-77-9 ;
PubChem CID	9867642;
IUPHAR/BPS	3356;
ChemSpider	8043333;
UNII	G7N11T8O78;
KEGG	D08940 ;
ChEMBL	ChEMBL426559 ;
CompTox Dashboard (EPA)	DTXSID60205756 ;
ECHA InfoCard	100.207.712
Chemical and physical data
Formula	C21H19ClFNO4S
Molar mass	435.89 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1cc(F)cc2c1n(c3c2CC[C@@H]3CC(=O)O)Cc4ccc(Cl)cc4)C;
	InChI InChI=1S/C21H19ClFNO4S/c1-29(27,28)18-10-15(23)9-17-16-7-4-13(8-19(25)26)20(16)24(21(17)18)11-12-2-5-14(22)6-3-12/h2-3,5-6,9-10,13H,4,7-8,11H2,1H3,(H,25,26)/t13-/m1/s1; Key:NXFFJDQHYLNEJK-CYBMUJFWSA-N;
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Niacin/laropiprant
Combination of
Niacin	Hypolipidemic agent
Laropiprant	Prostaglandin receptor antagonist
Clinical data
Trade names	Cordaptive, Tredaptive
AHFS/Drugs.com	UK Drug Information
License data	EU EMA: by laropiprant;
Routes of; administration	Oral
ATC code	C10AD52 (WHO) ;
Legal status
Legal status	Withdrawn;
Identifiers
PubChem CID	11948701;
CompTox Dashboard (EPA)	DTXSID60205756 ;
ECHA InfoCard	100.207.712
	(what is this?) (verify)

Laropiprant (INN) was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin.

Merck & Co. planned to market this combination under the trade names Cordaptive in the US and Tredaptive in Europe. Both brands contained 1000 mg of niacin and 20 mg of laropiprant in each tablet.^[1]

^ "Tredaptive Prescribing Information" (PDF). Merck & Co. Retrieved 2009-11-14.

[Tredaptive_pi-1] "Tredaptive Prescribing Information" (PDF). Merck & Co. Retrieved 2009-11-14.

Laropiprant information

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