Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections.[7] This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis.[7] It may be given by mouth or intravenously.[7]
Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.[7] Severe side effects may include liver problems, heart failure, Stevens–Johnson syndrome and allergic reactions including anaphylaxis.[7] It is unclear if use during pregnancy or breastfeeding is safe.[1] It is in the triazole family of medications.[7] It stops fungal growth by affecting the cell membrane or affecting their metabolism.[7]
Itraconazole was patented in 1978 and approved for medical use in the United States in 1992.[7][8] It is on the World Health Organization's List of Essential Medicines.[9]
Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway[10] in a similar way to sonidegib.
^ ab"Itraconazole Use During Pregnancy". Drugs.com. 20 March 2019. Retrieved 15 May 2020.
^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
^"Sporanox 10 mg/mL Oral Solution - Summary of Product Characteristics (SmPC)". (emc). 1 February 2018. Retrieved 15 May 2020.
^Isoherranen N, Kunze KL, Allen KE, Nelson WL, Thummel KE (October 2004). "Role of itraconazole metabolites in CYP3A4 inhibition". Drug Metabolism and Disposition. 32 (10): 1121–1131. doi:10.1124/dmd.104.000315. PMID 15242978. S2CID 6941636.
^"Sporanox (itraconazole) Capsules. Full Prescribing Information" (PDF). Janssen Pharmaceuticals, Inc. Archived from the original (PDF) on 17 May 2018. Retrieved 28 August 2016.
^ abVasilev NA, Surov AO, Voronin AP, Drozd KV, Perlovich GL (April 2021). "Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility". International Journal of Pharmaceutics. 599: 120441. doi:10.1016/j.ijpharm.2021.120441. PMID 33675927. S2CID 232135660.
^ abcdefgh"Itraconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
^Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 503. ISBN 9783527607495.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^Li K, Fang D, Xiong Z, Luo R (2019). "Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole". OncoTargets and Therapy. 12: 6875–6886. doi:10.2147/OTT.S223119. PMC 6711563. PMID 31692536.
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis...
in the lungs may require surgery. Systemic medications used include Itraconazole, posaconazole and amphotericin B. With treatment, most people will recover...
commonly used drug, but other newer antimycotic drugs, such as terbinafine, itraconazole, and fluconazole have started to gain acceptance. It may appear as thickened...
strategy for elderly persons with chronic insomnia. Ketoconazole and itraconazole have a profound effect on the pharmacokinetics of triazolam, leading...
chemotherapeutics such as doxorubicin, and antifungal medications such as itraconazole. Famotidine was developed by Yamanouchi Pharmaceutical Co. It was licensed...
effectiveness. Conversely, CYP3A4 inhibitors such as ketoconazole and itraconazole can increase its concentrations in the body and the risk for adverse...
metabolism and pharmacokinetics of enobosarm. The strong CYP3A4 inhibitor itraconazole was shown to have minimal to no influence on the pharmacokinetics of...
bioavailability. One example is itraconazole which is an antimycoticum known for its poor aqueous solubility. Upon introduction of itraconazole-on-SBA-15 formulation...
or scalp ringworm, systemic treatment with oral medications (such as itraconazole, terbinafine, and ketoconazole) may be given. To prevent spreading the...
action involves interfering with synthesis of the fungal cell membrane. Itraconazole (R51211), invented in 1984, is a triazole fungistatic antifungal agent...
disturbing the soil. Treatment is typically with an azole drug such as itraconazole for mild or moderate disease. In severe cases, patients are treated with...
sufficient. Alternatives to itraconazole are posaconazole, voriconazole, and fluconazole. Individuals taking itraconazole are monitored for hepatic function...
first-in-human trials in patients with solid tumors and Acute Myeloid Leukaemia. Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat...
modalities include oral terbinafine, oral itraconazole, and intermittent "pulse therapy" with oral itraconazole Fingernail infections can be treated in...
may help prevent the disease.[citation needed] Surgery combined with itraconazole may be given for up to year when the grains are black. Posaconazole is...
long or the condition worsens despite applying creams, terbinafine or itraconazole can be given by mouth. The benefits of the use of topical steroids in...
severe, recalcitrant or recurrent cases. Systemic therapies include itraconazole (200 mg daily for seven days) and fluconazole (150 to 300 mg weekly dose...
Medications that may be taken by mouth include terbinafine (76% effective), itraconazole (60% effective), and fluconazole (48% effective). They share characteristics...
more-potent, less-toxic triazoles (fluconazole and itraconazole) have replaced it. Itraconazole (400 mg/day) appears to have efficacy equal to that of...
risk, using the antifungal medication itraconazole, and is treatable with amphotericin B followed by itraconazole or voriconazole. The disease is fatal...
medication by other azole antifungal agents, such as fluconazole and/or itraconazole, because of ketoconazole's greater toxicity, poorer absorption, and more...
to its own nature or as a PPI. PPIs reduce absorption of antifungals (itraconazole and ketoconazole) and possibly increase digoxin in plasma Increases plasma...
half-life, leading to increased plasma levels and more pronounced effects. Itraconazole has a similar effect on zopiclone pharmacokinetics as erythromycin. The...
Whitfield's ointment or salicylic acid ointment. Topical antifungals or oral itraconazole are other options. Scraping the lesion can be curative. Prevention is...
clotrimazole or nystatin is usually effective. Oral or intravenous fluconazole, itraconazole, or amphotericin B may be used if these do not work. A number of topical...
Global Information
