Iron superoxide dismutase, with the active site in the inset.
Identifiers
EC no.
1.15.1.1
CAS no.
9054-89-1
Alt. names
FeSOD
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BRENDA
BRENDA entry
ExPASy
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KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB structures
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proteins
Iron superoxide dismutase (FeSOD) is a metalloenzyme that belongs to the superoxide dismutases family of enzymes. Like other superoxide dismutases, it catalyses the dismutation of superoxides into diatomic oxygen and hydrogen peroxide. Found primarily in prokaryotes such as Escherichia coli and present in all strict anaerobes,[1] examples of FeSOD have also been isolated from eukaryotes, such as Vigna unguiculata.[2]
Found within the cytosol, mitochondria, and chloroplasts,[3] FeSOD's ability to disproportionate superoxides provides cells with protection against oxidative stress and other processes that produce superoxides such as photosynthesis. It is important for organisms to disproportionate superoxides, as superoxides themselves are not particularly harmful but have the potential to turn into a hydroxyl radical, which is unable to be eliminated in an enzymatic reaction.[2]
^Morris JG, Hewitt J (15 February 1975). "Superoxide dismutase in some obligately anaerobic bacteria". FEBS Letters. 50 (3): 315–318. doi:10.1016/0014-5793(75)90058-7. PMID 163764.
^ abMuñoz IG, Moran JF, Becana M, et al. (23 May 2003). "Crystallization and preliminary X-ray diffraction studies of the eukaryotic iron superoxide dismutase (FeSOD) from Vigna unguiculata". Acta Crystallographica Section D: Structural Biology. 59 (6): 1070–1072. doi:10.1107/s0907444903006966. hdl:10261/99334. PMID 12777777.
^Cite error: The named reference sheng was invoked but never defined (see the help page).
and 25 Related for: Iron superoxide dismutase information
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Superoxidedismutase [Cu-Zn] also known as superoxidedismutase 1 or hSod1 is an enzyme that in humans is encoded by the SOD1 gene, located on chromosome...
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glutathione, mycothiol, or bacillithiol, and enzyme systems like superoxidedismutase, can prevent damage from oxidative stress. Known dietary antioxidants...
trials. Studies have shown that synthetic catalytic scavengers have superoxidedismutase and catalase activities which prevented injuries from reactive oxygen...
stabilization and is activated by copper chaperone for superoxidedismutase (CCS). Other isozymes may contain iron, manganese or nickel. The activity of Ni-SOD...
oxygen-producing photosynthesis, but which had not yet evolved enzymes (such as superoxidedismutase) for living in an oxygenated environment. Such organisms would have...
microbes, including obligate anaerobes. Aerobic organisms produce superoxidedismutase and catalase to detoxify these products, but obligate anaerobes produce...
ceruloplasmin, Cu/Zn superoxidedismutase, and in amine oxidases. These enzyme catalyze reactions for oxidative phosphorylation, iron transportation, antioxidant...
enzymatic activity of copper-zinc superoxidedismutase (SOD),—to protect organisms from the toxic effects of superoxide free radicals formed as a byproduct...
regulatory mechanisms modulate the expression of a dinoflagellate iron-superoxidedismutase". J. Biol. Chem. 276 (23): 19989–93. doi:10.1074/jbc.M101169200...
seawater. The dismutation of superoxide to hydrogen peroxide can also be catalyzed by the antioxidant enzyme superoxidedismutase with a rate constant on the...
nitrite formation from hydroxylammoniumchloride: a simple assay for superoxidedismutase". Anal. Biochem. 70 (2): 616–20. doi:10.1016/0003-2697(76)90488-7...
consumption. The best studied cellular antioxidants are the enzymes superoxidedismutase (SOD), catalase, and glutathione peroxidase. Less well studied (but...
bimetallic active sites. Examples include superoxidedismutase, urease, nickel-iron hydrogenase. Many Non-heme iron proteins have diiron active sites, e.g...
dismutation of superoxide free radical to hydrogen peroxide and oxygen, catalysed in living systems by the enzyme superoxidedismutase: 2 O 2 − + 2 H...
1016/s0968-0004(99)01390-0. PMID 10322429. McCord JM, Fridovich I (November 1969). "Superoxidedismutase. An enzymic function for erythrocuprein (hemocuprein)". The Journal...
combustion that produces ATP. Other copper proteins include some superoxidedismutases used in defense against free radicals, peptidyl-α-monooxygenase...
Increases the activity of antioxidant enzymes, specifically that of superoxidedismutase, responsible for the formation and consumption of lipid peroxides...
such as zinc and copper allowed them to displace iron and manganese from the enzyme superoxidedismutase (SOD). Fe and Mn complexes dissociate readily (Irving–Williams...
cancer metastasis and angiogenesis. Diethyldithiocarbamate inhibits superoxidedismutase, which can both have antioxidant and oxidant effects on cells, depending...
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