An immune disorder is a dysfunction of the immune system.[1] These disorders can be characterized in several different ways:
By the component(s) of the immune system affected
By whether the immune system is overactive or underactive
By whether the condition is congenital or acquired
According to the International Union of Immunological Societies, more than 150 primary immunodeficiency diseases (PIDs) have been characterized.[2] However, the number of acquired immunodeficiencies exceeds the number of PIDs.[3]
It has been suggested that most people have at least one primary immunodeficiency.[4] Due to redundancies in the immune system, though, many of these are never detected.
^Erjavec SO, Gelfman S, Abdelaziz AR, Lee EY, Monga I, Alkelai A, Ionita-Laza I, Petukhova L, Christiano AM (Feb 2022). "Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82". Nat Commun. 13 (1): 800. Bibcode:2022NatCo..13..800E. doi:10.1038/s41467-022-28343-3. PMC 8831607. PMID 35145093.
^Geha RS, Notarangelo LD, Casanova JL, et al. (October 2007). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee". J. Allergy Clin. Immunol. 120 (4): 776–94. doi:10.1016/j.jaci.2007.08.053. PMC 2601718. PMID 17952897.
^Kumar A, Teuber SS, Gershwin ME (2006). "Current perspectives on primary immunodeficiency diseases". Clin. Dev. Immunol. 13 (2–4): 223–59. doi:10.1080/17402520600800705. PMC 2270780. PMID 17162365.
^Casanova JL, Abel L (August 2007). "Primary immunodeficiencies: a field in its infancy". Science. 317 (5838): 617–9. Bibcode:2007Sci...317..617C. doi:10.1126/science.1142963. PMID 17673650. S2CID 7287315.
An immunedisorder is a dysfunction of the immune system. These disorders can be characterized in several different ways: By the component(s) of the immune...
of disorders that, despite their differences, share some common symptomatic threads. These shared symptoms occur as a result of the body's immune system...
and also impairs other immune system responses indirectly. Various hormonal and metabolic disorders can also result in immune deficiency including anemia...
produced in excessive quantities. These disorders primarily present in patients who have a compromised immune system. Due to this factor, there are instances...
syndrome. Immune reactions during pregnancy, both maternal and of the developing child, may produce neurodevelopmental disorders. One typical immune reaction...
Common variable immunodeficiency (CVID) is an inborn immunedisorder characterized by recurrent infections and low antibody levels, specifically in immunoglobulin...
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from...
cells (scientific name leukocytes), also called immune cells or immunocytes, are cells of the immune system that are involved in protecting the body against...
Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally. To be considered a primary...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that begins in early childhood, persists throughout adulthood, and affects two crucial...
flow cytometry. Giant platelet disorders can be further categorized: caused by auto-immunedisorders, for example Immune thrombocytopenic purpura (ITP)...
protozoa, through IgE signaling. Mast cell activation disorders (MCAD) are a spectrum of immunedisorders that are unrelated to pathogenic infection and involve...
Hypermobility spectrum disorder (HSD), related to earlier diagnoses such as hypermobility syndrome (HMS), and joint hypermobility syndrome (JHS) is a heritable...
diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant...
though the latter two may also reasonably be called an immunedisorder and a neurological disorder, respectively. Pichot, P. (1986). "[DSM-III: the 3d edition...
division. Problems with the body's immune system can lead to tumors. An autoimmune disorder is a condition where in the immune system attacks and destroys healthy...
The adaptive immune system, also known as the acquired immune system, or specific immune system is a subsystem of the immune system that is composed of...
an immunedisorder of children manifesting as eczema or other allergic conditions. It can include atopic myelitis, which causes weakness. Immune-mediated...
Idiopathic hypereosinophilic syndrome. Congenital disorders Hyperimmunoglobulin E syndrome, an immunedisorder characterized by high levels of serum IgE Omenn...
but was diagnosed with common variable immunodeficiency (CVID), an immunedisorder that has left her largely bedridden and isolated. It has also lead...
Hashimoto's encephalopathy: Arising from an auto-immunedisorder. Anti-NMDA receptor encephalitis: An auto-immune encephalitis. Hyperammonemia: A condition caused...
meningococcal disease Immune-mediated disease, any immunedisorder or any disease secondary to immune responses Inherited metabolic disorder, an inborn error...
efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression...
Immune thrombocytopenic purpura (ITP), also known as idiopathic thrombocytopenic purpura or immune thrombocytopenia, is an autoimmune primary disorder...
increases the risk of infection without affecting the risk of allergies or immunedisorders. Hygiene is essential for protecting vulnerable populations such as...
reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation. Non-immune diseases with causal origins in inflammatory...
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