Micrograph showing an opportunistic infection due to immunosuppression - large (blue) cell below-center-left infected with a polyomavirus. Urine cytology specimen.
ICD-10-PCS
D89.9
MeSH
D007165
[edit on Wikidata]
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.[1][2]
In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant.[3] Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, or Crohn's disease. This is typically done using medications, but may involve surgery (splenectomy), plasmapheresis, or radiation. A person who is undergoing immunosuppression, or whose immune system is weak for some other reasons (such as chemotherapy or HIV), is said to be immunocompromised.[4]
^"Immunodeficiency disorders: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 2017-05-06.
^"NCI Dictionary of Cancer Terms". National Cancer Institute. 2011-02-02. Retrieved 2017-05-06.
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive...
body size; an average man's BSA is 1.9 m2). Glucocorticoids cause immunosuppression, and the therapeutic component of this effect is mainly the decreases...
myelosuppression (decreased production of blood cells, hence that also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and...
problems and may work in general/internal medicine, transplant medicine, immunosuppression management, intensive care medicine, clinical pharmacology, perioperative...
(7%), and pneumonia (6%). These occur in part due to measles-induced immunosuppression. Less commonly seizures, blindness, or inflammation of the brain may...
opportunistic infection compared to the general population. Biologics for immunosuppression include adalimumab, certolizumab, etanercept, golimumab, infliximab...
Di Carlo E, Ferrini S (September 2006). "Targeting tumor-related immunosuppression for cancer immunotherapy". Endocrine, Metabolic & Immune Disorders...
host cells) immunoevasion, evasion of the host's immune response immunosuppression, inhibition of the host's immune response (this includes leukocidin-mediated...
apart from biopsy achieving a high accuracy rate. Treatment is with immunosuppression. The first case of sarcoidosis involving the nervous system was reported...
with fibrotic changes, organ transplant recipients, and those with immunosuppression. According to the Ohio Department of Health and US Department of Health...
Sleep deprivation, also known as sleep insufficiency or sleeplessness, is the condition of not having adequate duration and/or quality of sleep to support...
It has been reported that UV radiation leads to local and systemic immunosuppression, due to DNA damage and altered cytokine expression. This has implications...
virus, which remains latent until the body undergoes some form of immunosuppression. Typically, this is in the setting of kidney transplantation or multi-organ...
ultraviolet light, chemical carcinogens, recent injury to the skin, immunosuppression and genetic predisposition. As with squamous cell cancer, sporadic...
well as lowered requirements for external insulin. In all cases no immunosuppression was used, and the role of this medication was taken and provided by...
antibodies have a variety of specificities, their main mechanism of immunosuppression is through depletion of T cells. Thymoglobulin is currently approved...
but in excess causes sunburn, skin aging, DNA damage, skin cancer, immunosuppression, and eye damage, such as cataracts. The scale was developed by Canadian...
latter half of the 20th century due to increasing travel and rates of immunosuppression in the population. For people infected with HIV/AIDS, PCP is a common...
Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon...
evading host immune systems by producing microbial toxins and causing immunosuppression. Optimal virulence describes a theorized equilibrium between a pathogen...
Global Information