Global InformationP1PK blood group system information
P1PK (formerly: P) is a human blood group system (International Society of Blood Transfusion system 003) based upon the A4GALT gene on chromosome 22. The P antigen (later renamed P1) was first described by Karl Landsteiner and Philip Levine in 1927.[1] The P1PK blood group system consists of three glycosphingolipid antigens: Pk, P1 and NOR.[2][3] In addition to glycosphingolipids, terminal Galα1→4Galβ structures are present on complex-type N-glycans.[4] The GLOB antigen (formerly P) is now the member of the separate GLOB (globoside) blood group system.
- ^ Landsteiner, Karl; Levine, Philip (1927). "Further Observations on Individual Differences of Human Blood". Experimental Biology and Medicine. 24 (9): 941–942. doi:10.3181/00379727-24-3649. S2CID 88119106.
- ^ Kaczmarek, Radoslaw; Buczkowska, Anna; Mikolajewicz, Katarzyna; Krotkiewski, Hubert; Czerwinski, Marcin (2014). "P1PK, GLOB, and FORS blood group systems and GLOB collection: biochemical and clinical aspects. Do we understand it all yet?". Transfusion Medicine Reviews. 28 (3): 126–136. doi:10.1016/j.tmrv.2014.04.007. PMID 24895151.
- ^ Hellberg, Åsa Hellberg (2020). "P1PK: a blood group system with an identity crisis". ISBT Science Series. 15: 40–45. doi:10.1111/voxs.12505. S2CID 201971613.
- ^ Szymczak-Kulus, Katarzyna; Weidler, Sascha; Bereznicka, Anna; Mikolajczyk, Krzysztof; Kaczmarek, Radoslaw; Bednarz, Bartosz; Zhang, Tao; Urbaniak, Anna; Olczak, Mariusz; Park, Enoch Y.; Majorczyk, Edyta (January 2021). "Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry". Journal of Biological Chemistry. 296: 100299. doi:10.1016/j.jbc.2021.100299. ISSN 0021-9258. PMC 7949097. PMID 33460651.